P27
Luetjens CM, Fuchs A, Weinbauer GF. Covance Laboratories GmbH, Muenster, Germany. Evaluation of Fetal and Neonatal Skeletal Development in the Marmoset Callithrix Jacchus

P28
Buse E¹, Hui J², Habermann G¹. ¹Covance Laboratories GmbH, Muenster, NRW, Germany, ²Celgene Corporation, Summit, NJ, United States. The Placenta of Cynomolgus Monkeys–Expression of Feto-Maternal Tolerance Mechanisms

P29
Fuchs A, Niggemann B, Srivastav S, Weinbauer G. Covance Laboratories GmbH, Muenster, Germany. Intravitreal Injection in an Embryo-Fetal Development Study with Cynomolgus Monkeys (Macaca fascicularis)

P30
Meyer JK¹, Hess DL², Pau FK-Y², Chellman GJ¹. ¹Charles River Laboratories, Preclinical Services, Reno, NV, United States, ²Oregon National Primate Research Center, Beaverton, OR, United States. Interpreting Menstrual Cycling in Nonhuman Primate Reproductive Toxicology Studies: Need for Ovarian Hormone Data

P31
Lalayeva N, Oneda S, Kenfield J, Eyre R, Tsusaki H. SNBL United States, Ltd, Everett, WA, United States. Infant Data from Pre- and Post-Natal Development Studies in Cynomolgus Monkeys of Chinese, Cambodian, and Indonesian Origins

P32
Watson R¹, Kenfield J¹, Schielke J¹, Robison A¹, Berg E¹, Matsuyama T¹, Lalayeva N¹, Oneda S¹, Eyre R¹, Tsusaki H¹, Nagata R². ¹SNBL USA, Everett, WA, United States, ²Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan. Development of Twin Cynomolgus Macaques Reared by a Foster Dam in a Laboratory Environment

P33
Coburn A, Stedman D. Drug Safety Research & Development, Pfizer Inc., Groton, CT, United States. Understanding the Predictivity of a Zebrafish Developmental Toxicity Assay

P34
Hermsen SAB^1,2, Pronk TE^1,2, van den Brandhof E-J¹, van der Ven LTM¹, Piersma AH^1,3. ¹National Institute for Public Health and the Environment, Bilthoven, Netherlands, ²Maastricht University, Maastricht, Netherlands, ³Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands. Class-Specific Gene Expression Changes in the Zebrafish Embryo after Exposure to Three Glycol Ether Alkoxy Acids and Two 1,2,4-Triazole Antifungals

P35
Smith MA¹, West FD^2,3, Henderson WM⁴, Yu P^2,3, Stice SL^2,3. ¹College of Public Health, Environmental Health Science Department, University of Georgia, Athens, GA, United States, ²Department of Animal and Dairy Science, University of Georgia, Athens, GA, United States, ³Regenerative Bioscience Center, University of Georgia, Athens, GA, United States, ⁴National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, GA, United States. Characterization of the Endocrine Response of Human Embryonic Stem Cell Derived Germ Like Cells After Exposure to Steroid Hormones

P36
Jeffay S¹, Barrier M¹, Nichols H¹, Chandler K^1,2, Singh A³, Knudsen T², Hunter S¹. ¹Integrated Systems Toxicology Division, NHEERL, US EPA, Research Triangle Park, NC, United States, ²National Center for Computational Toxicology, ORD, US EPA, Research Triangle Park, NC, United States, ³Lockheed Martin, Research Triangle Park, NC, United States. Effects of the ECVAM Chemical Validation Library on Differentiation using Marker Gene Expression in Mouse Embryonic Stem Cells

P37
Wegner S, Hong S, Kim H, Park J, Yu X, Faustman EM. University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA, United States. In Vitro Neural Progenitor Cells as a Model for Neurodevelopment

P38
Piersma AH^1,2, Rorije E¹, Beekhuijzen MEW⁷, Cooper R³, Dix DJ³, Heinrich-Hirsch B⁶, Martin MT³, Mendez E⁴, Muller A¹, Papparella M⁹, Ramsingh D⁵, Reaves E⁴, Ridgway P⁸, Schenk E¹, Stachiv L⁵, Ulbrich B⁶, Hakkert BC¹. ¹RIVM, Bilthoven, Netherlands, ²IRAS, Utrecht University, Utrecht, Netherlands, ³ORD-USEPA, Raleigh, NC, United States, ⁴OPP-USEPA, Washington, DC, United States, ⁵PMRA Health Canada, Ottawa, ON, Canada, 6BfR, Berlin, Germany, ⁷NOTOX, Den Bosch, Netherlands, ⁸HSE, Bootle, United Kingdom, ⁹Environment Agency Austria, Vienna, Austria. Combined Retrospective Analysis of 498 Rat Multi-Generation Reproductive Toxicity Studies: On The Impact of Parameters Related to F1 Mating and F2 Offspring

P39
Rountree MR¹, DeWoskin RS², Kleinstreuer NC¹, Sipes NS¹, Chandler KJ^1,3, Singh AV⁴, Spencer RM⁴, Knudsen TB¹. ¹USEPA/ORD/NCCT, Research Triangle Park, NC, United States, ²USEPA/ORD/NCEA, Research Triangle Park, NC, United States, ³USEPA/ORD/NHEERL, Research Triangle Park, NC, United States, ⁴Lockheed Martin, Research Triangle Park, NC, United States. Modeling Limb-Bud Dysmorphogenesis in a Predictive Virtual Embryo Model

P40
Mylchreest E, Daniels KK. Southern Research, Birmingham, AL, United States. Comparison of the Reproductive Performance of Harlan Sprague-Dawley Rats Fed Two Different Diets

P41
Hilbish KG, Cohen IR. Eli Lilly and Company, Indianapolis, IN, United States. An Assessment of the Prolactin Response to Nursing in Female Rats on Postnatal Day 4

P42
Wise LD¹, Dogsas B¹, Winkelmann CT¹, Pais H². ¹Merck Research Laboratories, West Point, PA, United States, ²Definiens Inc., Parsippany, NJ, United States. Semi-Automatic Evaluation of Fetal Rabbit Skull Bones by Micro-CT Image Analysis

P43
Hartke LE, Milius AD, Gilmore RG, Wahle BS, Dandekar DS. Xenometrics LLC, Stilwell, KS, United States. Fixation-Induced Raised Zones within the Cranial Vault of the Rat Fetus

P44
Adamo M, Barbeau S, Martin AI, Varela A, Samadfam R, Smith SY, Pouliot L, Robinson K. Charles River Laboratories, Preclinical Services, Montréal, Senneville, QC, Canada. Post Natal Skeletal Development Assessments in Non-Clinical Pediatric Studies

P45
Richard-Tremblay AA^1,2, Sheehy O¹, Audibert F¹, Ferreira E^1,2, Bérard A^1,2. ¹CHU Ste-Justine Research Center, Montreal, QC, Canada, ²Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada. Concordance between Preconceptional and Periconceptional Vitamin/Folic Acid Supplementation and the Joint SOGC-MOTHERISK Clinical Guidelines

P46
Agyekum AK, Sheenan K, Edwards K. University of Georgia, Athens, GA, United States. Probiotics Reduce Pathogen Invasion in Fetal and Neonatal Tissues

P47
Brenseke BM¹, Bahamonde J¹, Gutierrez JC^1,2, Prater MR^1,3. ¹VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States, ²Facultad de Ciencias Veterinarias Universidad Austral de Chile, Valdivia, Chile, ³Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States. Maternal High Fat Diet Results in Poor Birth Outcome and Impaired Physical Development

P48
Martin AI, Primakova I, Adamo M, Robinson K. Charles River Laboratories, Preclinical Services Montreal Inc., Senneville, QC, Canada. Effects of Oral Gavage Dosing on Postnatal Development and Growth of NZW Rabbit Kits

P49
Logsdon AL¹, Herring BJ¹, Lockard JE¹, Miller BM¹, Brady JA¹, Calderon EA¹, Janzen ER¹, Rasco JF², Hood RD^2,3, Bailey MM¹. ¹Emporia State University, Emporia, KS, United States, ²The University of Alabama, Tuscaloosa, AL, United States, ³Ronald D. Hood & Associates, Tuscaloosa, AL, United States. Evaluation of Effects of Prior Exposure to Green Tea Extract on Cyclophosphamide Teratogenesis in CD-1 Mice

P50
Laureano RT¹, Birkebak JM¹, Schroeder RE², Faqi AS², Hui JY¹. ¹Celgene Corporation, Summit, NJ, United States, ²MPI Research, Mattawan, MI, United States. The Beagle Dog as an Alternate Species for Embryo-Fetal Development Studies

P51
Narotsky MG. U.S. Environmental Protection Agency, ORD, Research Triangle Park, NC, United States. Comparison of Birth- and Conception-Based Definitions of Postnatal Age in Developmental and Reproductive Rodent Toxicity Studies: Influence of Gestation Length on Measurements of Offspring Body Weight and Puberty in Controls

P52
Herring BJ¹, Logsdon AL¹, Miller BM¹, Lockard JE¹, Lovich AN¹, Calderon EA¹, Brady JA¹, Rasco JF², Hood RD^2,3, Swatloski RP^4,5, Rogers RD^4,5, Bailey MM¹. ¹Department of Biological Sciences, Emporia State University, Emporia, KS, United States, ²Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States, ³Ronald D. Hood & Associates, Tuscaloosa, AL, United States, ⁴Department of Chemistry, University of Alabama, Tuscaloosa, AL, United States, ⁵Center for Green Manufacturing, University of Alabama, Tuscaloosa, AL, United States. Toxicity of Short-Chain Imidazolium-Based Ionic Liquids in CD-1 Mice: Influence of the Anion

P53
Moyer BJ, Hixon ML. Brown University, Providence, RI, United States. Late Gestational Exposure to Ubiquitous Plasticizer Mono-2-Ethylhexyl Phthalate (MEHP) Results in Abnormal Adult Reproductive Endpoints: Effects on Female Mouse Reproductive Development

P54
Sammarco M¹, Macrini DJ¹, Rodrigues PA¹, Ricci EL^2,3, Bernardi MM^1,3. ¹Paulista University, São Paulo, Brazil, ²Mackenzie University, São Paulo, Brazil, ³São Paulo University, São Paulo, Brazil. Behavioral Sexual Dimorphic Toxicity to Glyphosate in Mice Treated during Puberty with the Herbicide

P55
Kaufman FL, Kim AN, Campbell MA, Wu KL, Donald JM. Office of Environmental Health
Hazard Assessment/Cal EPA, Sacramento, CA, United States. Sulfur Dioxide–Evidence of Reproductive and Developmental Toxicity

P56
Nichols H, Barrier M, Jeffay S, Chandler K, Simmons S, Hunter S. Integrated Systems Toxicology Division, NHEERL, ORD, US EPA, Research Triangle Park, NC, United States. Assessment of a 42 Metal Salts Chemical Library in Mouse Embryonic Stem Cells

P57
Leconte I¹, Mouche I¹, Malésic L¹, Kerbrat M¹, Brunet G¹, Hofmann T², Gillardeaux O¹. ¹Covance, Porcheville, France, ²sanofi-aventis R&D, Frankfurt, Germany. FETAX Correlation with In Vivo Embryotoxicity Studies and Comparison to Danio rerio Teratogenesis Assay (DarT)

P58
Hueza IM¹, Elias F², Haraguchi M³, Górniak SL². ¹Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, Brazil, ²Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Universidade de São Paulo, São Paulo, Brazil, ³Instituto Biológico de São Paulo, São Paulo, Brazil. A Postnatal Evaluation of the Immunotoxic Effect of Integerrimine N-oxide Exposure during Gestation to Rats

P59
Mariano DP¹, Pinheiro ML¹, Paulino CA², Maiorka PC³, Górniak SL¹. ¹Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil, ²University Bandeirante of São Paulo, São Paulo, SP, Brazil, ³Laboratory of Experimental and Comparative Neuropathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil. Assessment of the Perinatal Effects of Maternal Ingestion of Senna occidentalis Seeds: Study in Rats

P60
Liaw J¹, Portman RJ², Hixson CJ¹, Tomlinson L¹, Horvath JJ¹, McNerney M¹. ¹Drug Safety Evaluation, Bristol Myers Squibb Research and Development, New Brunswick, NJ, United States, ²Global Clinical Research, Bristol Myers Squibb Research and Development, Princeton, NJ, United States. Juvenile Toxicity Assessment of Irbesartan in Rats: Comparison of Neonatal versus Weanling Dose Initiation

P61
Silva MH. California Environmental Protection Agency, Sacramento, CA, United States. Hazard Identification for Reproductive and Developmental Toxicity of Simazine

P62
Rengasamy P¹, Shafiulla M², Saeed T², Singh S². ¹Mercer University School of Medicine, Macon, GA, United States, ²UAE University, Al Ain, United Arab Emirates. How Does Streptozotocin (STZ) Induce Pregnancy Failure in the Mouse?

P63
Ellis-Hutchings RG¹, Rasoulpour RJ¹, Terry C², Gollapudi BB¹, Billington R². ¹Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, United States, ²Dow AgroSciences LLC, Indianapolis, IN, United States. Mode of Action Evaluation and Human Relevance Analysis for X11422208-Induced Fetal Abnormalities and Neonatal Death in Rats

P64
Hrubec TC^1,2, Cullen R². ¹E. Via College of Osteopathic Medicine, Blacksburg, VA, United States, ²VA-MD Regional College of Veterinary Medicine, VA Tech, Blacksburg, VA, United States. Pre-Breeding Maternal Immune Stimulation Alters Cytokine Concentrations During Pregnancy

P65

Melin V¹, Hrubec T^1,2. ¹Virginia Tech, Department of Biomedical Sciences and Pathobiology, Blacksburg, VA, United States, ²E Via College of Osteopathic Medicine, Blacksburg, VA, United States. Further Characterization of a Teratogen Present in Water