Developmental Toxicity Testing of Cigarette Smoke and E-Cigarette Vapor Utilizing Drosophila melanogaster Primary Embryonic Stem Cell Cultures
Ubina TM, Juarez J, Gallardo M, Bournias-Vardiabasis N. California State University–San Bernardino, San Bernardino, CA, United States.
10:30 AM-10:45 AM
2
Oxidative Stress-Induced Harm Reduction Tobacco Products Misregulates the Development of Bone
Sparks NRL, Walker LM, Sera S, zur Nieden NI. University of California–Riverside, Riverside, CA, United States.
10:45 AM-11:00 AM
3
Genetic Screening for Ethanol-Sensitive Zebrafish Mutants Identifies a Requirement for Bmp Signaling in Endoderm and Jaw Development
Lovely CB, Swartz ME, McCarthy N, Norrie JL, Henegar T, Eberhart JE. University of Texas–Austin, Austin, TX, United States.
11:00 AM-11:15 AM
Break-Aspen Foyer
11:15 AM-11:30 AM
4
Harm-Reduction Tobacco Products Deleteriously Alter AKT and Other Survival-Related Signaling Pathways during Normal Embryonic Osteogenesis
Walker LM, Sparks NRL, zur Nieden NI. University of California-Riverside, Riverside, CA, United States.
11:30 AM-11:45 AM
5
Changes to Primary Cilia Number and Function in the Neural Tube Following Neurulation-Stage Ethanol Exposure in a Mouse Model of FASD Boschen KE, Fish EW, van Venrooy AI, Parnell SE. University of North Carolina, Chapel Hill, NC, United States.
11:45 AM-12:00 Noon
6
Complex Mixtures of Anti-Androgens at Concentrations below Individual Chemical Effect Levels Produces Reproductive Tract Malformations in the Male Rat Conley JM1, Lambright CR1, Evans N1, Cardon MC1, Medlock-Kakaley E1,2, Wilson VS1, Gray LE1. 1US EPA/ORD/NHEERL/TAD/RTB, Research Triangle Park, NC, United States, 2US EPA-UNC Cooperative Toxicology Program, Research Triangle Park, NC, United States.
12:00 Noon-12:15 PM
7
Folic Acid As a Radioprotectant: Efficacy in Preventing X-Ray Induced Congenital Malformations Craenen K1,2, Verslegers M1, Craeghs L1,2, Buset J1, Neefs M1, Baatout S1, Moons L2, Benotmane MA1. 1Radiobiology Unit, SCK-CEN, Mol, Belgium, 2Neural Circuit Development and Regeneration Research Group, KUL, Leuven, Belgium.
12:15 PM-12:30 PM
8
Effect of Maternal Depression and Prenatal Antidepressant Exposure on Placental Serotoninergic and Glucocorticoids Systems Methylation Laurent L1, Peñaherrera M2,3, Robinson WP2,3, Oberlander TF2,3, Vaillancourt C1. 1INRS-Institut Armand Frappier, Laval, QC, Canada, 2BC Children's Hospital Research Institute, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada.
12:30 PM-12:45 PM
9
Regional Differences and Correlates of Prevalence of Prenatal Alcohol Exposure in Texas As Assessed by PEth in Newborn Dry Blood Spots Shrestha S1, Williams S1, Miranda R2, Bakhireva L1. 1University of New Mexico, Albuquerque, NM, United States, 2Texas A&M Health Science Center, College of Medicine, Bryan, TX, United States.
12:45 PM-1:00 PM
10
Genomic Variations in Ebstein Anomaly and Cardiomyocyte Differentiation Giannakou AG1, Sicko SRJ2, Kay KDM2, Fan FR5, Jelliffe-Pawlowski PLL3, Shaw SG4, Mills JLM1. 1National Institutes of Health, NICHD, DIPHR, Bethesda, MD, United States, 2Wadsworth Center, NYSDOH, Albany, NY, United States, 3University of California–San Francisco, School of Medicine, San Francisco, CA, United States, 4Stanford School of Medicine, Stanford, CA, United States, Georgetown University, Washington, DC, United States.
Project Newborn: What We Have Learned from 20 Years of Research on Prenatal Cocaine Exposure?
(Joint with DNTS)
Chairperson: Janee Gelineau-van Waes, Creighton University School of Medicine and Patricia A. Janulewicz Lloyd, Boston University School of Public Health
Lecturer: Sonia Minnes, Case Western Reserve University
3:35 PM–6:30 PM
WILEY-BLACKWELL SYMPOSIUM
Developmental Metabolism: Consequences to and from Neural Lineages – Aspen Ballroom
Chairpersons and Scientific Liaison Coalition Representatives: Thomas B. Knudsen, National Center for Computational Toxicology, US EPA and Mary Alice Smith, University of Georgia
3:35 PM–3:50 PM
Introduction
3:50 PM–4:25 PM
S1
Molecular Pathology of Neural Tube Defects in Diabetic Pregnancies
J. Michael Salbaum, Pennington Biomedical Research Center, LSU
4:25 PM-4:40 PM
Break - Aspen Foyer
4:40 PM–5:15 PM
S2
Apoptotic Mechanism of Maternal Diabetes-Induced Neural Tube Defects
Peixin Yang, University of Maryland–Baltimore
5:15 PM–5:50 PM
S3
Development of Neuroendocrine Systems Governing Energy Homeostasis
Chen Liu, UT Southwestern University
5:50 PM–6:25 PM
S4
Modeling of Developmental Neurotoxicity Using Pluripotent Stem Cell-Derived Neurons and Astrocytes is Generating New Mechanistic Insights
Chairpersons: Christina D. Chambers, University of California-San Diego and Lewis B. Holmes, MassGeneral Hospital for Children
3:35 PM–3:40 PM
Welcome and Introduction
Lewis B. Holmes, MassGeneral Hospital for Children
3:40 PM–4:00 PM
S5
The Key Role of Social Media in Registry Recruitment
Nicole Chavez, Communications Consultant
4:00 PM–4:20 PM
S6
"Drugs in Breast Milk": Related Data in Pregnancy Registries
Shinya Ito, The Hospital for Sick Children
4:20 PM–4:35 PM
Break - Aspen Foyer
4:35 PM–4:55 PM
S7
How to Interpret Different Findings for the Same Medication Across Pregnancy Registries: The Example of Keppra
David Miller, UCB Biosciences, Inc
4:55 PM–5:15 PM
S8
Incorporating Registry Data into the Label—Guidance for the PLRR
Leyla Sahin, US Food and Drug Administration
5:15 PM–5:30 PM
S9
Defect Evaluation by Infant Photographs in a Multi-Center Pharmaceutical Clinical Trial Scheuerle AE1, Kwon P2, Joing M2. 1University of Texas Southwestern Medical Center, Dallas, TX, United States, 2NORA Therapeutics, Inc., Palo Alto, CA, United States.
5:30 PM–5:45 PM
S11
Distribution by Week and Trimester of Onset among Pregnant Women, US Zika Pregnancy Registry, 2015–2016 Khan S1, Rice ME1, Reynolds MR1, Reagan-Steiner S1, Brown CM5, Lee EH4, Ahmad N2, Macdonald J3, Sommer JN2, Smith LC2, Honein MA1. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2New York State Department of Health, Albany, NY, United States, 3Virginia Department of Health, Richmond, VA, United States, 4New York City Department of Health and Mental Hygiene, Queens, NY, United States, 5Massachusetts Department of Public Health, Boston, MA, United States.
5:45 PM–6:00 PM
S10
Prevalence of Small for Gestational Age and Preterm Birth Among Infants Born to Women with Laboratory Evidence of Possible Zika Virus Infection During Pregnancy, US Zika Pregnancy Registry, December 2015–December 2016 Fleck-Derderian S1, Jones AM1, Simon EL1, Newsome K1, Lee EH2, Ahmad N3, Dunn JE4, Smith LC3, White JL3, Honein MA1. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2New York City Department of Health and Mental Hygiene, New York City, NY, United States, 3New York State Department of Health, Albany, NY, United States, 4Massachusetts Department of Public Health, Boston, MA, United States.
6:00 PM–6:15 PM
S12
Pregnancy and Lactation Labeling Rule (PLLR) in Practice: More Human Observational Data Needed Wurst KE1, Cunnington M3, Powell M2, Lee TJ1. 1GlaxoSmithKline, Collegeville, PA, United States, 2GlaxoSmithKline, Research Triangle Park, NC, United States, 3GlaxoSmithKline, Stevenage, United Kingdom.
6:15 PM–6:30 PM
S13
Lactation Study Challenges and Solutions Hurst N1, Covington D2. 1PPD, Inc., Morrisville, NC, United States, 2Evidera, Wilmington, NC, United States.
6:35 PM–7:00 PM
CELEBRATING THE LIFE OF THOMAS H. SHEPARD – Aspen Ballroom
(Joint with OTIS)
Chairpersons: Sonja A. Rasmussen, Centers for Disease Control and Prevention and Stephen R. Braddock, Saint Louis University School of Medicine
Speakers: Elaine M. Faustman, University of Washington (S14) and
Godfrey P. Oakley Jr., Emory University (S15)
Evaluation of Fetal Risk in the Context of Multiple Co-Exposures
Chairpersons: Ludmila Bakhireva, University of New Mexico and Jeffrey R. Wozniak, University of Minnesota
9:15 AM–9:25 AM
Introduction: Methodological Challenges of Evaluating the Effect of Multiple Exposures
Ludmila Bakhireva, University of New Mexico
9:25 AM–9:50 AM
S16
Defining the Human Exposome
Cynthia F. Bearer, University of Maryland
9:50 AM–10:15 AM
S17
PK/PD Modelling for Multiple Exposures in Pregnancy
Donald R. Mattison, Risk Sciences International
10:15 AM–10:40 AM
Networking Break – Aspen Foyer
10:40 AM–11:05 AM
S18
Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs)
Rajesh C. Miranda, Texas A&M Health Sciences Center
11:05 AM–11:30 AM
S19
Epigenetic Changes Induced by Prenatal Nicotine and Cocaine Exposure
Pradeep Bhide, Florida State University
11:30 AM–11:35 AM
Concluding Remarks
Jeffrey R. Wozniak, University of Minnesota
11:35 AM–12:00 Noon
Panel Discussion
9:05 AM–11:45 AM
PLATFORM SESSION 2 – Colorado Ballroom B
Mechanistic and Clinical Teratology
Chairpersons: John M. DeSesso and Amy L. Williams, Exponent, Inc.
Presenting author is underlined.
9:05 AM-9:15 AM
Introduction
9:15 AM-9:30 AM
11
Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay Palmer JA, Smith AM, Colwell MR, Smart BJ, Ludwig MA, Burrier RE, Donley ELR, Kirchner FR. Stemina Biomarker Discovery, Inc., Madison, WI, United States
9:30 AM-9:45 AM
12
DNA Hypermethylation in Tight Junction Pathway Is Associated with Neural Tube Defects: A Genome-Wide DNA Methylation Analysis Ren A1,2, Wang LL1,2, Lin S1,2, Zhang J1,2, Tian T1,2, Huang Y1,2. 1Institute of Reproductive and Child Health, Peking University, Beijing, China, 2Ministry of Health Key Laboratory of Reproductive Health, Peking University, Beijing, China.
9:45 AM-10:00 AM
13
Toxicogenomic Profiling of BDE-47 Effects in Human Primary Villous Cytotrophoblasts Robinson JF, Hamilton EG, Ona K, Puckett KA, Kapidzic M, Fisher SJ. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, United States.
10:00 AM-10:15 AM
14
Targeted Dnmt3a Deletion Ameliorates Maternal Diabetes-Induced DNA Hypermethylation and Neural Tube Defects Yang P, Xu C, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States.
10:15 AM-10:30 AM
15
VDR Regulates Skeleton Development through MiR-140-5p by Transcriptional Regulation Luo W, Yang L, Dong Y, Kong J, Yuan Z, Zhao Q. Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
10:30 AM-10:45 AM
Break—Aspen Foyer
10:45 AM-11:00 AM
16
Biliary Atresia and Maternal Nutrient Intake Carmichael SL1, Ma C1, Van Zutphen A2,3, Moore CA4, Shaw GM1. 1Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States, 2Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY, United States, 3Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Rensselaer, NY, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States.
11:00 AM-11:15 AM
17
Challenges of Species Selection for Development and Reproductive Toxicity Studies with A Dopamine Agonist Zhuang Q, Rasmussen AD, Jensen KG, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark.
11:15 AM-11:30 AM
18
Justifying Mandatory Food Fortification with Folic Acid: Benefits Beyond Preventing Neural Tube Defects Mills JL. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, United States.
11:30 AM-11:45 AM
19
An Evaluation of Household Environments and Zika Risk Perceptions, Prevention Behaviors, and Prevention Knowledge among Pregnant Women in Puerto Rico Turay KR1, Earle-Richardson G1, Medina-MartÃnez G2, Romero-Pérez M2, Chavez P3, Vega MC5, Thomas D4,5, Rivera-Garcia B5, Prue C1. 1Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, United States, 2Caduceus Staffing, Atlanta, GA, United States, 3Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, United States, 4Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Atlanta, GA, United States, 5Puerto Rico Department of Health, San Juan, PR, United States.
12:00 Noon–1:30 PM
LUNCH ON YOUR OWN
12:00 Noon–1:30 PM
PAST PRESIDENTS' AND HONOREES' LUNCHEON – Maroon Peak
(By Invitation Only)
12:00 Noon–1:30 PM
MEMBERSHIP COMMITTEE MEETING – Mt. Yale
12:00 Noon–1:30 PM
PUBLIC AFFAIRS COMMITTEE MEETING – Mt. Princeton
1:30 PM–4:50 PM
MARCH OF DIMES SYMPOSIUM – Aspen Ballroom The Complexities of Caring for the Pregnant and Lactating
Patient with Chronic Inflammatory Disease: Maternal and Fetal Considerations
(Joint with OTIS)
Chairpersons: Christina D. Chambers, University of California-San Diego and Melissa S. Tassinari, Independent Consultant
1:30 PM–1:35 PM
Introduction
1:35 PM–1:55 PM
S20
Overview: Complexity of Disease Management in Pregnancy and Lactation, Consequences of Chronic Disease Itself and Polypharmacy, Use of Asthma and Lupus As Examples
Megan E.B. Clowse, Duke University
1:55 PM–2:15 PM
S21
Case Study: Asthma in Pregnancy
Jennifer A. Namazy, Scripps Clinic Mission Valley
2:15 PM–2:35 PM
S22
Case Study: Lupus in Pregnancy
Megan E.B. Clowse, Duke University
2:35 PM–2:55 PM
S23
Missing Data
Christine Stallman, University of Arizona and MotherToBaby Arizona
2:55 PM–3:15 PM
S24
Long Term Effects of Maternal Factors on Child’s Risk for Autism and Other Neurodevelopmental Concerns
Irva Hertz-Picciotto, University of California-Davis
3:15 PM–3:35 PM
S25
Chronic Maternal Immune Mediated Diseases and Their Treatments: How Do We Design Good Quality Studies to Evaluate Neurodevelopment in the Offspring?
Gail S. Ross, Cornell University
3:35 PM–3:50 PM
Break - Aspen Foyer
3:50 PM–4:10 PM
S26
Lactation and Medications
Philip O. Anderson, University of California-San Diego
4:10 PM–4:30 PM
S27
Pregnancy and Lactation Labeling Rule (PLLR): Placement of Human Data in Labeling
Chairpersons: Susan Y. Euling, US Environmental Protection Agency and Suzanne E. Fenton, National Institute of Environmental Health Sciences
1:30 PM–2:15 PM
S28
Species Differences in Mammary Gland Development and Susceptibility to Environmental Chemicals: Human–Animal Species Comparisons
Ana M. Soto, Tufts University
2:15 PM–2:55 PM
S29
Male Rat Mammary Gland Effects after Developmental Exposure to Environmental Chemicals
Suzanne E. Fenton, National Institute of Environmental Health Sciences
2:55 PM–3:35 PM
S30
Genesis of Male Breast Cancer: An Epidemiologic Perspective
Louise A. Brinton, Division of Cancer Epidemiology and Genetics, NCI
3:35 PM–3:50 PM
Break – Aspen Foyer
3:50 PM–4:30 PM
S31
The Role of Environmental Factors in Pubertal Gynecomastia
Susan Y. Euling, US Environmental Protection Agency
4:30 PM–5:10 PM
S32
The Development of Pubertal Gynecomastia and the Association to Endogenous Hormones, Growth, and Body Composition
Mikkel G. Mieritz, Rigshospitalet
5:10 PM–5:30 PM
Discussion
5:30 PM–7:30 PM
POSTER SESSION 1 AND EXHIBITS ATTENDED – Capitol Peak Ballroom (Joint with DNTS and OTIS)
Society for Birth Defects Research and Prevention Posters P1–P14
DNTS Posters 1-21
OTIS Posters 1–14
P1Overview of Zika en Embarazadas y Niños en Colombia (ZEN): A Prospective
Cohort Study Examining Zika Virus Infection during Pregnancy and Risk of
Adverse Pregnancy, Birth, and Infant Outcomes Colombian Instituto Nacional de Salud1,
US Centers for Disease Control and Prevention2, Anderson KN2.
1Colombian Instituto Nacional de Salud, Bogota, Colombia, 2US
Centers for Disease Control and Prevention, Atlanta, GA, United States.
P2Assessing Teratogenicity from the Clustering of
Abnormal Phenotypes in Individual Zebrafish Larvae Ali S2, Aalders J1,
Jong T1, Richardson M1. 1Sylvius Laboratory, Institute
of Biology, Leiden University, Leiden, The Netherlands, 2Department of
Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
P3Quantitative Prediction of Microcephaly
Utilizing Cell Agent-Based Modeling: Profiling the Centrosome Cycle Zurlinden TJ1, Saili KS1,
Spencer RS2, Baker NC2, Knudsen TB1. 1National
Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United
States, 2Leidos, Research Triangle Park, NC, United States.
P4Computational Modeling of the Neurovascular
Unit to Predict Microglia Mediated Effects on Blood-Brain Barrier Formation Zurlinden TJ1, Saili KS1,
Spencer RS2, Baker NC2, Knudsen TB1. 1National
Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United
States, 2Leidos, Research Triangle Park, NC, United States.
P5Cardiovascular Ultrasound of Neonatal Long
Evans Rats Exposed Prenatally to Trichloroacetic Acid: Effects on Heart Rate,
Ejection Fraction, and Cardiac Output Narotsky MG1, Thompson LC2,
Manley AL3, Ola O4. 1Toxicity Assessment Division,
ORD, US Environmental Protection Agency, Research Triangle Park, NC, United States,
2Environmental & Public Health Division, US Environmental Protection Agency,
Research Triangle Park, NC, United States, 3Oak Ridge Institute for Science
and Education, US Environmental Protection Agency, Research Triangle Park, NC, United
States, 4Student Contractor, US Environmental Protection Agency, Research
Triangle Park, NC, United States.
P6Hazard Screening Approaches for Identifying
Developmental and Reproductive Toxicity in the Workplace Pacheco Shubin SE1, Cohen JM2, Dodge DG3,
Lewandowski TA1. 1Gradient, Seattle, WA, United States,
2Gradient, Cambridge, MA, United States, 3Gradient, Bend, OR, United
States.
P7Systems Toxicology Model of Neurovascular
Development Saili KS1, Zurlinden TJ1,
Baker NC2, Knudsen TB1. 1National Center for Computational
Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos,
Research Triangle Park, NC, United States.
P8Orofacial Clefting in Response to Hedghog
Pathway Antagonists is Recapitulated in a Practical
Epithelial–Mesenchymal 3D Culture Model Johnson BP2, Vitek RM2,
Fink DM1, Chung H1, Geiger P2, Beebe DJ2,
Lipinski RJ1. 1University of Wisconsin, Department of Comparative
Biosciences, Madison, WI, United States, 2University of Wisconsin, Department
of Biomedical Engineering, Madison, WI, United States.
P9Developmental Neurotoxicity after Exposure to
Pesticides: Adding a Biotransformation Component Impacts the Pathways Affected
in Human Neural Progenitor Cells (hN2) McKenzie EM1, Amosu OM1,
Smith MA1, Stice SL1,2. 1University of Georgia,
Athens, GA, United States, 2ArunA Biomedical, Inc, Athens, GA, United
States.
P10Characterizing the Effect of Embryonic Ethanol
Exposure on Cranial Nerve Development in Zebrafish Embryos Mutant for the
Ethanol-Sensitive Allele, vangl2 Buckley DM, Eberhart
JK. University of Texas–Austin, Austin, TX, United States.
P11The Effects of Quaternary Ammonium Compounds on
Development of the Microbiome McDonald VA1, Hrubec TC2.
1Department Biological Sciences, VA Tech, Blacksburg, VA, United States,
2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United
States.
P12Abundance of Household Products Contain
Quaternary Ammonium Compounds Hrubec TC1,2, DiPeppi R1.
1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United
States, 2VA-MD College of Veterinary Medicine, Blacksburg, VA, United
States.
P13Follow the White Rabbit: Does the Source of
Time-Mated New Zealand White Rabbits Impact Maternal or Developmental
Parameters? Olitan TA, Rayhon SL, McNerney ME, Thompson KE. Bristol-Myers Squibb, New Brunswick,
NJ, United States.
P14A Comparison of the Embryofetal Development
Data Collected from New Zealand White (Crl:KBL[NZW]) Rabbits at Several
Teratology Laboratories Pouliot L1, Marsden E2,
Lewis EM3, Robinson K1. 1Charles River, Montréal,
QC, Canada, 2Charles River, Lyon, France, 3Charles River,
Horsham, PA, United States.
Society for Birth Defects Research and Prevention Posters P15–P43
P15Zika Related Birth Defect Surveillance in
Missouri Wambuguh L, Garrett L, Sapkota A, McCarthy
E. Missouri Department of Health and Senior Services, Bureau of Vital Statistics,
Jefferson City, MO, United States.
P16An Evaluation of the New Zealand White Rabbit
Model for Zika Virus Infection during Gestation and Microcephaly in the
Offspring O'Hara MF1, Ramachandra R2. 1Covance Drug Development,
Greenfield, IN, United States, 2Covance Immunology Services, Denver,
PA, United States.
P17Behavioral Screening of the LOPAC1280 Library
Reveals that Zebrafish Embryos are Unable to Discriminate Modes of Action for
Neuroactive Compounds Vliet SM1,2, Ho TC2,
Volz DC2. 1Environmental Toxicology Graduate Program, University
of California–Riverside, Riverside, CA, United States, 2Department
of Environmental Sciences, University of California–Riverside, Riverside,
CA, United States.
P18Evaluation of Maternal Transplacental Transfer
of Anti-F-Antibodies to Pups Following Immunization of Pregnant Hartley Guinea
Pigs with a Recombinant Respiratory Syncytial Virus Vaccine Murphy CJ, Goodnight SY, Murphy L,
Godin CS. Smithers Avanza, Gaithersburg, MD, United States.
P19Maternal Diabetes Suppresses Mitochondrial
Fusion Leading to Heart Defects through the miR-195-Mitofusin 1/Mitofusin 2
Circuit Zhong J, Yang P. University of Maryland
School of Medicine, Baltimore, MD, United States.
P20The Development of Type 2 Diabetes in Nonobese
Male Swiss-Webster Mice: Effect of Exposure to a Gluten-Free Diet Kepko DS1, Wells C1,
Boornazian A2, Gosstola N2, Smith H2, Wing B2,
Munagala A2, Thigpen H2, Rasco JF2, Bailey MM1.
1Emporia State University, Emporia, KS, United States, 2University
of Alabama, Tuscaloosa, AL, United States.
P21Survival of Infants with Spina Bifida and the
Role of Maternal Pre-Pregnancy Body Mass Index Pace ND1, Siega-Riz AM1,
Olshan AF1, Chescheir NC2, Cole SR1, Desrosier
TA1, Tinker SC3, Hoyt AT4, Canfield MA4,
Carmichael SL5, Meyer RE6, The National Birth Defects Prevention
Study3. 1Department of Epidemiology, University of North Carolina–Chapel
Hill, Chapel Hill, NC, United States, 2Department of Obstetrics and Gynecology,
Division of Maternal Fetal Medicine, University of North Carolina–Chapel Hill,
Chapel Hill, NC, United States, 3National Center on Birth Defects and
Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta,
GA, United States, 4Birth Defects Epidemiology and Surveillance Branch,
Texas Department of State Health Services, Austin, TX, United States, 5Department
of Pediatrics, Division of Neonatology and Developmental Medicine, Stanford University
School of Medicine, Stanford, CA, United States, 6Birth Defects Monitoring
Program, North Carolina Department of Health and Human Services, Raleigh, NC, United
States.
P22Computational Toxicology and Computational
Modeling of Embryonic Limb Development Using ToxCast High-Throughput Screening
Data Ahir B1, Spencer R2,
Baker N2, Judson R3, Martin M3, Knudsen T3.
1University of Illinois College of Medicine at Chicago, Chicago, IL,
United States, 2Lockheed Martin, US EPA, Research Triangle Park, NC,
United States, 3National Center for Computational Toxicology, US EPA,
Research Triangle Park, NC, United States.
P23A 3D Organotypic Human Stem Cell Model to
Evaluate Human Palatal Fusion Wolf CJ, Belair DG, Becker CM, Abbott
BD. US Environmental Protection Agency, Research Triangle Park, NC, United States.
P24Assessment of Developmental Toxicity Potential
of Glyphosate-Based Herbicides Using Drosophila melanogaster Primary
Embryonic Stem Cell Cultures Argueta JA, Torres A. California State
University–San Bernardino, San Bernardino, CA, United States.
P25Behavioral Profiling of Zebrafish Embryos Exposed
to a Panel of Sixty Water-Soluble Compounds Ali S1, Champagne D2,
Richardson M2. 1Department of Zoology, The University of Azad
Jammu and Kashmir, Muzaffarabad, Pakistan, 2Sylvius Laboratory, Institute
of Biology, Leiden University, Leiden, The Netherlands.
P26Teratological Effects of a Panel of Sixty
Water-Soluble Toxicants on Zebrafish Development Ali S1, Aalders J2, Richardson M2. 1Department
of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan,
2Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The
Netherlands.
P27Developmental Toxicity of Leucomalachite Green
on Zebrafish Wan H, Zhang H. Guangdong Zhongke EnHealth Technology Co., Ltd., Foshan, China.
P28Effect of Neonatal Abstinence Syndrome on
Neurodevelopmental Outcomes at Six Months of Age in Infants Born to Women on
Medication-Assisted Treatment for Opioid Use Disorder Ashley M, Holbrook BD, Cano S, Lowe
J, Stephen JM, Qeadan F, Leyva Y, Rayburn W, Leeman L, Bakhireva L. University of
New Mexico Health Sciences Center, Albuquerque, NM, United States.
P29Developmental Toxicity of Dimethadione and
Acetylsalicylic Acid in Rats Toy H1, Harris SB2,
Mylchreest E1. 1Battelle, West Jefferson, OH, United
States, 2Stephen B. Harris Group, San Diego, CA, United States.
P30Exposure to QACs Alters Inflammatory Responses
in Murine Macrophages Nguyen HD1, McDonald VA2,
Hrubec TC1,3. 1E. Via College of Osteopathic Medicine, VA
Campus, Blacksburg, VA, United States, 2Department Biological Sciences,
Virginia Tech, Blacksburg, VA, United States, 3VA-MD College of Veterinary
Medicine, Blacksburg, VA, United States.
P31Validation of and Disparities with Prevalence
of Congenital Microcephaly: New York State 2013–2015 Fox D1, Brady L1,
Pantea C1, Graham K2, Talati A2, Browne M1,
Carter S3, Friedenberg E3, Vora N3,4, Lee C3,5.
1Congenital Malformations Registry, New York State Department of Health,
Albany, NY, United States, 2Public Health/Preventive Medicine Residency
Program, New York City Department of Health and Mental Hygiene, New York City, NY,
United States, 3Division of Disease Control, New York City Department
of Health and Mental Hygiene, New York City, NY, United States, 4Office
of Public Health Preparedness and Response, CDC, New York City, NY, United States,
5Epidemic Intelligence Service, CDC, New York City, NY, United States.
P32Sex and Dose-Related Differences in Behavior
Following Excess Taurine Consumption by B6 Mice during Adolescence and Early
Adulthood Villalona YE, Weimer JL, Massie LA,
Marczinski CA, Curran CP. Northern Kentucky University, Highland Heights, KY, United
States.
P33From Inhibition of Retinoic Acid Catabolism to
Facial Malformations: Suggestions for a New Adverse Outcome Pathway Di Renzo F1, Moretto A1,2,
Eberini I1, Beronius A3, Zilliacus J3, Hanberg
A3, Menegola E1. 1Università degli Studi di Milano,
Milan, Italy, 2ICPS ASST Fatebenefratelli Sacco, Milan, Italy, 3Karolinska
Instituted, Stockholm, Sweden.
P34In Vitro Embryo Exposure to Retinoic Acid, Valproic Acid, Ethanol, and to the
Antifungal Prochloraz Alone or in Mixture: Effects on Cranio-Facial
Morphogenesis Menegola E1, Bacchetta R1,
Battistoni M1, Di Renzo F1, Metruccio F2, Moretto
A1,2. 1Università degli Studi di Milano, Milan, Italy,
2ICPS ASST Fatebenefratelli Sacco, Milan, Italy.
P35Inflammogenic and Vascular Effects of Acute
Pulmonary Exposure to Titanium Dioxide Nanoparticles Abukabda AB, McBride CR, Nurkiewicz TR. West Virginia University, Morgantown, WV, United
States.
P36Battery of Reproductive Toxicology Studies
Supporting the Safety of a Dopamine Receptor Antagonist, Molindone Krishna G1, Gopalakrishnan G1, Yu C1, Ganiger S2,
White T3. 1Supernus Pharmaceuticals, Inc., Rockville, MD,
United States, 2Advinus Therapeutics Ltd., Bengaluru, Karnataka, India,
3Aclairo Pharmaceutical Development Group, Inc., Vienna, VA, United States.
P37Intersecting Principles of Teratology and
Toxicology in Nursing Education and Community Engagement Dodd-Butera T1, Shaputnic
C2. 1California State University, San Bernardino, CA, United
States, 2University of California Institute for Fetal Alcohol Spectrum
Disorders Discovery, San Diego, CA, United States.
P38Effects of Quaternary Ammonium Compounds on
Neural Stem/Progenitor Cells Meade HA1, Shea CS2,
Hrubec TC2,3. 1Department of Biochemistry, Virginia Tech,
Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine,
VA Campus, Blacksburg, VA, United States, 3VA-MD College of Veterinary
Medicine, Virginia Tech, Blacksburg, VA, United States.
P39Ontogeny of the Central Nervous System across
Species Williams AL1, DeSesso JM1,2.
1Exponent, Inc., Alexandria, VA, United States, 2Georgetown
University School of Medicine, Washington, DC, United States.
P40Alcohol Exacerbates the Teratogenic Effects of
Prenatal Cannabinoid Exposure in a C57BL/6J Mouse Model Fish EW1, Boschen KE1,
Murdaugh LB1, Mendoza-Romero HN1, Williams KP2,
Parnell SE1. 1University of North Carolina, Chapel Hill, NC,
United States, 2North Carolina Central University, Durham, NC, United
States.
P41Evaluation of Ad Libitum Feeding in
Pregnant Rabbits Rayhon SL, Seethala RK, McNerney ME,
Thompson KE. Bristol-Myers Squibb Company, New Brunswick, NJ, United States.
P42Ocular Evaluations in Juvenile Dutch Belted
Rabbits Robinson KJ, Martin AI, Pouliot L,
Vezina M. Charles River, Montréal, QC, Canada.
P43Post
Natal Cardiovascular Assessment in Juvenile Beagle Dogs Using Telemetry Adamo M, Primakova I, Kirouac A, Norton
K, Robinson K. Charles River, Montréal, QC, Canada.
Redesigning the Embryofetal Developmental Toxicity Study: Evolution or Revolution?
Chairpersons: George P. Daston, Procter & Gamble Company and Anthony R. Scialli, Scialli Consulting LLC
1:30 PM–2:00 PM
W6
Hypothesis-Driven Approaches for Assessing Developmental Toxicity
George P. Daston, Procter & Gamble Company
2:00 PM–2:30 PM
W7
In Vitro Data and In Silico Models for Computational Toxicology
Thomas B. Knudsen, National Center for Computational Toxicology, US EPA
2:30 PM–3:15 PM
W8
Redesigning the Embryofetal Developmental Toxicity Study: Revolution–Changing the Approach
Aldert Piersma, RIVM
3:15 PM–3:30 PM
Break
3:30 PM–3:45 PM
W9
Improving Dose-Response Assessment in Developmental Toxicity Testing and Risk Assessment
Sue Makris, US Environmental Protection Agency
3:45 PM–4:00 PM
W10
Humanized Experimental Models
Alan Hoberman, Charles River Laboratories
4:00 PM–4:15 PM
W11
Models of Animal Disease
Kary E. Thompson, Bristol-Myers Squibb and Pragati Sawhney Coder, Charles River Ashland
4:15 PM–4:30 PM
Discussion
1:30 PM–4:30 PM
PLATFORM SESSION 3 – Colorado Ballroom B
Clinical Teratology
Chairpersons: Jeffrey H. Charlap, Charles River Laboratories and Pragati Sawhney Coder, Charles River Ashland
1:30 PM–1:45 PM
Introduction
1:45 PM–2:00 PM
21
Fine Mapping for Genetic Susceptibility to Valproic Acid-Induced Exencephaly in Mice
Lei Y, Wlodarczyk BJ, Cabrera RM, Finnell RH. Dell Medical School, Austin, TX, United States.
2:00 PM–2:15 PM
22
In Utero Exposure to the Pesticide Synergist and Sonic Hedgehog Signaling Inhibitor Piperonyl Butoxide Causes Holoprosencephaly in Mice
Everson JL, Lipinski RJ. University of Wisconsin–Madison, Madison, WI, United States.
2:15 PM–2:30 PM
23
Gene-Environment Interactions in Holoprosencephaly Muenke M1, Kruszka P1, Addissie Y1, Troia A2, Kozel B2, Everson J3, Malecki K4, Lipinski R3. 1National Human Genome Research Institute, NIH, Bethesda, MD, United States, 2National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States, 3Department of Comparative Biosciences, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States, 4Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States.
2:30 PM–2:45 PM
24
Hypospadias, Intrauterine Growth Restriction, and Abnormalities of the Placenta
Toufaily MH1, Roberts D2, Westgate M-N1, Hunt A-T3, Holmes LB1. 1MassGeneral Hospital for Children, Boston, MA, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Hunt Consulting Associates, Chapel Hill, NC, United States.
2:45 PM–3:00 PM
25
Changes in Serum Lipid Profiles in Neonatal Monkeys Associated with Sevoflurane-Induced Neurotoxicity Slikker W1, Wang C2, Han X2, Liu F1, Gu Q1, Liu S1, Patterson T1, Paule M1, Hanig J3, Wang C1. 1National Center for Toxicological Research, US FDA, Jefferson, AR, United States, 2Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, United States, 3Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, United States.
3:15 PM–3:30 PM
26
Maternal Antihypertensive Medication Use and Selected Birth Defects in the National Birth Defects Prevention Study Fisher SC1, Van Zutphen AR1,2, Werler MM3, Romitti PA4, Cunniff CM5. 1Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 2Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, United States, 3Department of Epidemiology, School of Public Health, Boston University, Boston, MA, United States, 4Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States, 5Department of Pediatrics, Weill Cornell Medical College, New York, NY, United States.
3:30 PM–3:45 PM
27
A Mysterious Story of Embryo-Foetal Developmental Toxicity in Rats with AX Zhuang Q, Rasmussen AD, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark.
3:45 PM–4:00 PM
28
Birth Outcomes following Pregnancy Exposure to Adalimumab: The OTIS Autoimmune Diseases in Pregnancy Project Chambers CD1, Johnson DL1, Xu R1, Luo Y1, Adam MP2, Braddock SR3, Robinson L4, Vaux K1, Jones KL1, The OTIS Collaborative Research Group1. 1University of California–San Diego, La Jolla, CA, United States, 2University of Washington, Seattle, WA, United States, 3Saint Louis University, St. Louis, MO, United States, 4University at Buffalo, Buffalo, NY, United States.
4:00 PM–4:15 PM
29
Birth Defect Surveillance As a Requirement for Reducing Birth Defects in a Developing Country Fakoya FA1, Wade A2. 1St. George's University II, Newcastle Upon Tyne, United Kingdom, 2St. George's University, St. George's, Grenada.
4:15 PM–4:30 PM
30
Clinical Variability of the Congenital Zika Syndrome Del Campo M1, Feitosa IML2, Garcia-Alix A3, Schuler-Faccini L2. 1University of California–San Diego, San Diego, CA, United States, 2Universidade Federal de Rio Grande do Sul, Porto Alegre, RGDS, Brazil, 3Institut de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Catalunya, Spain.
