Wednesday, July 2, 2014 |
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| 6:30 AM–7:30 AM |
Society for Birth Defects Research and Prevention 33RD ANNUAL VOLLEYBALL GAME – Tyee Community Gym |
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| 7:00 AM–4:30 PM |
REGISTRATION – Grand Ballroom Foyer |
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| 7:00 AM–4:30 PM |
SPEAKER READY ROOM OPEN – Grand Ballroom Foyer |
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| 8:00 AM–8:30 AM |
ROBERT L. BRENT LECTURE: TERATOGEN UPDATE – Grand Ballroom E |
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Teratology and Public Health: Working Together to Make Recommendations for Pregnant Women in the Face of Uncertainty (L8) |
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Chairperson: Mary Alice Smith, University of Georgia |
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Lecturer: Sonja A. Rasmussen, Centers for Disease Control and Prevention |
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8:30 AM–11:45 PM |
WILEY-BLACKWELL SYMPOSIUM – Grand Ballroom E
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From Fleas to Fish and Beyond: Advances in Alternative Assays to Predict Developmental Toxicity |
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Chairpersons: Robert G. Ellis-Hutchings and Bethany R. Hannas, The Dow Chemical Company and
E. Sid Hunter III, US Environmental Protection Agency |
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| 8:30 AM–8:40 AM |
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Introduction |
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| 8:40 AM–9:10 AM |
S24 |
Prediction of Developmental Toxicity Using Mouse Embryonic Stem Cells on Environmental Chemicals |
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E. Sid Hunter III, US Environmental Protection Agency |
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| 9:10 AM–9:40 AM |
S25 |
Daphnia as a Whole-Animal Invertebrate Model System for Human Health Research |
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Julia M. Gohlke, University of Alabama, Birmingham |
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| 9:40 AM–10:25 AM |
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Warkany Tea |
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| 10:25 AM–10:55 AM |
S27 |
Using Embryonic Zebrafish and Multidimensional Screening to Evaluate Neurobehavioral Toxicity and Teratology |
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Robert Tanguay, Oregon State University |
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| 10:55 AM–11:25 AM |
S28 |
Applications of Multiple Developmental Toxicology Assays for Teratogenic Hazard Identification and Mechanistic Evaluation |
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Karen A. Augustine, Bristol Myers Squibb Research Institute |
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| 11:25 AM–11:45 AM |
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Discussion |
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12:15 PM–1:30 PM |
LUNCH ON YOUR OWN |
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| 12:15 PM–1:30 PM |
BDRA EDITORIAL BOARD MEETING – Evergreen Ballroom G |
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| 12:15 PM–1:30 PM |
EDUCATION COMMITTEE MEETING – Evergreen Ballroom H |
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1:30 PM–4:30 PM |
PUBLIC AFFAIRS COMMITTEE SYMPOSIUM – Grand Ballroom E |
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Thrombosis during Pregnancy: Risks, Prevention and Treatment for Mother and Fetus |
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Chairpersons: Emmanuel Fadiran, Office of Women's Health, US FDA and Evi Struble, Center for Biologics Evaluation and Research, US FDA |
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Organized by the Public Affairs Committee |
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| 1:30 PM–1:45 PM |
S29 |
Thrombosis: Molecular Mechanisms, Clinical Picture, and Treatment Options during Pregnancy: An Introduction |
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Lisa Soule and Evi Struble, US Food and Drug Administration |
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| 1:45 PM–2:20 PM |
S30 |
Thrombosis in Pregnancy and Maternal Outcomes |
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Andra H. James, University of Virginia |
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| 2:20 PM–2:55 PM |
S31 |
Thrombophilia in Pregnancy and Fetal Outcome: Special Emphasis on Antiphospholipid Syndrome (APLS) |
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Sarah Gloria Obican, Columbia University and
Asher Ornoy, Israel Ministry of Health and Hebrew University |
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| 2:55 PM–3:10 PM |
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Break |
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| 3:10 PM–3:45 PM |
S32 |
Management of Thrombosis in Pregnancy |
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Barbara Konkle, Puget Sound Blood Center |
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| 3:45 PM–4:20 PM |
S33 |
Harvesting the Power of `Omic Technology, Biomarkers and In Vitro or In Vivo Models to Facilitate the Treatment of Thrombosis |
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Michael Paidas, Yale University |
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| 4:20 PM–4:30 PM |
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Panel Discussion and Closing Remarks |
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Evi Struble, Center for Biologics Evaluation and Research, US FDA |
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| 1:30 PM–4:30 PM |
PLATFORM SESSION 5 – Grand Ballroom A |
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In Vitro, Stem Cells, and Alternative Approaches |
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Chairpersons: : Kimberly Brannen, Charles River Laboratories and Deborah K. Hansen, US Food and Drug Administration |
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| 1:30 PM–1:45 PM |
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Introduction |
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| 1:45 PM–2:00 PM |
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Propofol-Induced Toxicity in Embryonic Neural Stem Cells and the Potential Protective Effect of Acetyl-L-Carnitine |
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Slikker Jr. W, Liu F, Rainoseck SW, Sadovova N, Fogle CM, Patterson TA, Hanig JP, Paule MG, Wang C. US Food and Drug Administration, NCTR, Jefferson, AR, United States. |
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| 2:00 PM–2:15 PM |
36 |
Effect of Growth Factors on Stem Cell Transplantation in Rat Fetuses with Spina Bifida Aperta |
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Yuan Z, Li H, Cao S, Gu H. Shengjing Hospital, China Medical University, Shenyang, China. |
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| 2:15 PM–2:30 PM |
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Short-Term Embryonic Stem Cell Exposure Assay As a Tool to Predict Developmental Toxicity |
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Sun Y2, Jergil M1, Stockling K3, Hellmold H3, Dencker L1, Gustafson A-L3, Salter H2, Stigson M1. 1Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 2AstraZeneca Translational Science Centre at the Karolinska Institutet, Solna, Sweden, 3AstraZeneca Global Safety Assessment, AstraZeneca R&D, Södertälje, Sweden. |
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| 2:30 PM–2:45 PM |
38 |
Using Human Pluripotent Cells to Detect Teratogens and Study Teratogenic Mechanisms |
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Flamier A1, Rasmussen T1,2,3. 1University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT, United States, 2University Connecticut Stem Cell Institute, Farmington, CT, United States, 3University Connecticut Institute for Systems Genomics, Storrs, CT, United States. |
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| 2:45 PM–3:00 PM |
39 |
Pathway Dynamics of an Organotypic In Vitro Testicular Model Reflect Developmental Processes In Vivo |
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Wegner S, Harris S, Stanaway I, Pacheco S, Park J, Hong S, Faustman EM. University of Washington, Seattle, WA, United States. |
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| 3:00 PM–3:15 PM |
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Break |
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| 3:15 PM–3:30 PM |
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An In Vitro Assay As a Screening Tool for Listeria monocytogenes Invasion in Maternal and Fetal Tissues |
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Wadhwa DR, Amosu M, Smith MA. University of Georgia, Athens, GA, United States. |
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| 3:30 PM–3:45 PM |
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The Effects of Carbamazepine and Valproic Acid on Gene Expression in a Human Embryonic Stem Cell Based Assay for Neuro-Developmental Toxicity |
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Schulpen SHW1,2, de la Fonteyne LJJ1, de Klerk A1, Piersma AH1,2. 1Centre for Health Effects Research, RIVM, Bilthoven, Netherlands, 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands. |
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| 3:45 PM–4:00 PM |
42 |
The Effects of the Zebrafish Chorion on the Response to Exogenous Chemicals |
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Gurrola-Gal MC1, Penney LC2, MacDougall J2, Clipston AS2, Brannen KC1. 1Preclinical Services, Charles River Laboratories, Horsham, PA, United States, 2Preclinical Services, Charles River Laboratories, Tranent, Edinburgh, United Kingdom. |
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| 4:00 PM–4:15 PM |
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Presence of Macrophages in an In Vitro Testicular Coculture Model of Male Reproductive Development Enhances Relevance to In Vivo Conditions |
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Pacheco SE, Wegner S, Green F, Harris S, Faustman EM. University of Washington, Seattle, WA, United States. |
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| 4:15 PM–4:30 PM |
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A Novel Human Embryoid Body System (hEB) with Potential to Be Used for Screening Drug Candidates in the Field of Reproductive Toxicology |
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Allison T1, Powles-Glover NS2, Stewart J2, Andrews PW1. 1The University of Sheffield, Sheffield, Yorkshire, United Kingdom, 2AstraZeneca, DSM, Mereside, Alderley Edge, Cheshire, United Kingdom. |
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| 4:45 PM–6:15 PM |
BUSINESS MEETING – Grand Ballroom E |
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| 6:30 PM–7:30 PM |
BANQUET RECEPTION – Evergreen Ballroom Foyer |
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| 7:30 PM–11:00 PM |
BANQUET – Evergreen Ballroom |
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Travel Awards
James C. Bradford Memorial Student Poster Awards
Wilson Presentation Awards
Marie W. Taubeneck Award
Birth Defects Research Distinguished Scholar Awards
Distinguished Service Award
Recognition of Other Awards Presented Throughout the Week |
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