Monday, June 30, 2014 |
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| 7:00 AM–8:00 AM |
DINE WITH A TERATOLOGY AMBASSADOR – Juniper
(Advance Signup Required) |
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| 7:00 AM–8:00 AM |
BDRB EDITORIAL BOARD MEETING – Evergreen Ballroom G |
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| 7:00 AM–6:00 PM |
REGISTRATION – Grand Ballroom Foyer |
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| 7:00 AM–6:00 PM |
SPEAKER READY ROOM OPEN – Grand Ballroom Foyer |
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| 8:00 AM–9:00 AM |
SPECIAL LECTURE (JOINT WITH NBTS) – Grand Ballroom E
Systems Medicine and Proactive P4 Medicine: Revolution in Healthcare (L3)
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Chairperson: Elaine Z. Francis, Sandcastle Toxicology Associates |
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Lecturer: Leroy Hood, Institute for Systems Biology |
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| 9:00 AM–12:00 Noon |
MARCH OF DIMES SYMPOSIUM – Grand Ballroom E |
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Advances in Early Diagnosis of Birth Defects and Adverse Perinatal Outcomes |
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Chairpersons: Ludmila Bakhireva, University of New Mexico and
Sarah G. Obican, Columbia University |
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| 9:00 AM–9:05 AM |
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Introduction |
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| 9:05 AM–9:40 AM |
S12 |
Smart Skin Sensors and Analytics in the Cloud to Advance the Frontiers of Wearable Health |
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Todd P. Coleman, University of California, San Diego |
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| 9:40 AM–10:15 AM |
S13 |
Screening for Birth Defects and Teratogen Risks with Ultrasonography in Early Gestation |
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William F. Rayburn, University of New Mexico |
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| 10:15 AM–10:30 AM |
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Break |
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| 10:30 AM–11:05 AM |
S14 |
The Role of the First Trimester Fetal Echocardiography in Identification of Birth Defects |
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Lynn L. Simpson, Columbia University |
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| 11:05 AM–11:40 AM |
S15 |
Fetal MRI as an Adjunct to Second Trimester Ultrasound |
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Jennifer A. Jolley, University of Washington School of Medicine |
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| 11:40 AM–12:00 Noon |
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Discussion |
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| 9:00 AM–12:00 Noon |
PLATFORM SESSION 2 – Grand Ballroom A |
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Mechanisms |
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Chairpersons: Barbara D. Abbott, US Environmental Protection Agency and Peixin Yang, University of Maryland School of Medicine |
| 9:00 AM–9:15 AM |
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Introduction |
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| 9:15 AM–9:30 AM |
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Inhibition of Valproic Acid-Induced Malformation through Nrf2 Activation |
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Hansen J1, Sant K2, Jilek J2, Harris C2. 1Emory University, Atlanta, GA, United States, 2University of Michigan, Ann Arbor, MI, United States. |
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| 9:30 AM–9:45 AM |
12 |
Decreased miR-322 and Increased Its Target Gene, TRAF3, a Proapoptotic Factor Leading to Caspase Activation in Diabetic Embryopathy |
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Gu H, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States. |
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| 9:45 AM–10:00 AM |
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Cdk1-Dependent Phosphorylation of Leukemia-Associated RhoGEF (LARG) during Mitosis |
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Helms MC1, Grabocka E1, Martz MK1, Suzuki N2, Wedegaertner PB1. 1Thomas Jefferson University, Philadelphia, PA, United States, 2University of Tokyo, Meguro, Tokyo, Japan. |
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| 10:00 AM–10:15 AM |
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Novel Mode of Defective Neural Tube Closure in the Nonobese Diabetic (NOD) Mouse Strain |
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Kappen C, Kruger C, MacGowan J, Herion N, Salbaum JM. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States. |
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| 10:15 AM–10:30 AM |
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Break |
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| 10:30 AM–10:45 AM |
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Predictive Models of Skeletal Developmental Defects from ToxCast High-Throughput Screening Data |
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Ahir BK1, Sipes NS1, Baker NC2, Leung MCK1, DeWoskin RS3, Spencer RM2, Judson RS1, Martin MT1, Knudsen TB1. 1National Center for Computational Toxicology, US Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC, United States, 2Lockheed Martin, Research Triangle Park, NC, United States, 3National Center for Environmental Assessment, Research Triangle Park, NC, United States. |
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| 10:45 AM–11:00 AM |
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Unique Susceptibility of the Rat to Leydig Cell Tumors Mediated by Pronamide-Induced Testosterone Metabolism |
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Rasoulpour RJ1,2, Andrus AK1, Marty S1, Zhang F1, Thomas J1, LeBaron MJ1, Papineni S2, Pottenger LH1, Hannas BR1, Eisenbrandt DL2. 1The Dow Chemical Company, Midland, MI, United States, 2Dow AgroSciences, Indianapolis, IN, United States. |
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| 11:00 AM–11:15 AM |
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Mechanisms in Distal Reproductive Tract Development |
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Zhao F1, Li R1, Dudley EA1, Zhou J1, Huang S2, Ye X1. 1University of Georgia, Athens, GA, United States, 2Georgia Regents University, Augusta, GA, United States. |
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| 11:15 AM–11:30 AM |
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Juvenile Toxicity Assessment of a Novel Antihyperglycemic Agent in Post-Weaned Rats |
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De Schaepdrijver LM1, Stannard D2, De Jonghe S1, Proctor J3, Bailey GP1, Mamidi R3, Johnson MD3. 1Preclinical Development & Safety, Janssen Research & Development, Beerse, Belgium, 2Huntingdon Life Sciences Ltd., Eye, Suffolk, United Kingdom, 3Preclinical Development & Safety, Janssen Research & Development, Raritan, United States. |
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| 11:30 AM–11:45 AM |
19 |
Epigenetic Modifications of Histone H3 in Brains of Fetal DNA Repair-Deficient Oxoguanine Glycosylase 1 (ogg1) Knockout Mice Exposed Once In Utero to Ethanol |
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Bhatia S1, Shapiro AM1, Wells PG1,2. 1Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. |
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| 11:45 AM–12:00 Noon |
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Activation of Human Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ) by House Dust Extracts |
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Wolf CJ1, Fang M2, Stapleton HM2, Abbott BD1. 1Toxicity Assessment Division, NHEERL, ORD, US EPA, Research Triangle Park, NC, United States, 2Nicholas School of the Environment, Duke University, Durham, NC, United States. |
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| 12:00 Noon–1:30 PM |
PAST PRESIDENTS' AND HONOREES' LUNCHEON – Juniper |
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(By Invitation Only) |
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12:00 Noon–1:30 PM |
LUNCH ON YOUR OWN |
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| 12:00 Noon–1:30 PM |
PUBLIC AFFAIRS COMMITTEE – Laurel |
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| 12:00 Noon–1:30 PM |
PUBLICATIONS COMMITTEE – Evergreen Ballroom G |
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1:30 PM–2:30 PM |
ELSEVIER DISTINGUISHED LECTURER (JOINT WITH NBTS) – Grand Ballroom E |
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Epigenetic Mechanisms in Intellectual Developmental Disabilities (L4) |
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Chairpersons: Thomas M. Burbacher, University of Washington and
Robert M. Greene, Birth Defects Center, University of Louisville
Lecturer: J. David Sweatt, The University of Alabama, Birmingham School Medicine |
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| 2:30 PM–5:30 PM |
TS/NBTS JOINT SYMPOSIUM – Grand Ballroom E |
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Epigenetics |
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Chairpersons: Thomas M. Burbacher, University of Washington and
Robert M. Greene, Birth Defects Center, University of Louisville |
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| 2:30 PM–2:45 PM |
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Introduction |
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| 2:45 PM–3:30 PM |
S16 |
Environmentally-Induced Epigenetic Transgenerational Inheritance of Disease: Ancestral Ghosts in Your Genome |
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Michael K. Skinner, Washington State University |
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| 3:30 PM–3:45 PM |
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Break |
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| 3:45 PM–4:30 PM |
S17 |
Chromatin Remodeling, miRNAs and Determination of Neurogenic Cell Fate |
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Andrew S. Yoo, Washington University School of Medicine |
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| 4:30 PM–5:15 PM |
S18 |
Mechanisms of MicroRNA Function in Fetal Neural Stem Cells: Implications for Ethanol Teratology |
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Rajesh C. Miranda, Texas A&M Health Science Center |
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| 5:15 PM–5:30 PM |
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Discussion |
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2:30 PM–5:30 PM |
PLATFORM SESSION 3 – Grand Ballroom A |
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Pregnancy Registry and Public Policy |
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Chairpersons: Marlissa A. Campbell, Office of Environmental Health Hazard Assessment and Leyla Sahin, US Food and Drug Administration |
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| 2:30 PM–2:45 PM |
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The Need for a Disease-Specific Prospective Pregnancy Registry for Multiple Sclerosis (MS) |
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Alwan S1, Chambers CD2, Sadovnick AD1. 1University of British Columbia, Vancouver, BC, Canada, 2University of California, San Diego, La Jolla, CA, United States. |
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| 2:45 PM–3:00 PM |
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US FDA Systematic Review and Preliminary Analysis of Pregnancy Registries |
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Sahin L1, Gelperin K2, Hammad H2, Nguyen M3, Woo J3, Iyasu S2. 1US FDA, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD, United States, 2US FDA, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Silver Spring, MD, United States, 3US FDA, Center for Biologics Evaluation and Research, Rockville, MD, United States. |
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| 3:00 PM–3:15 PM |
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The Navigation Guide Systematic Review Methodology Proof of Concept: PFOA and Fetal Growth |
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Johnson PI1, Sutton P1, Atchley D1, Koustas E2,
Lam J3, Sen S4, Robinson K5, Axelrad D6, Woodruff TJ1. 1University of California, San Francisco, CA, United States, 2Oak Ridge Institute for Science and Education (ORISE), Office of Policy, US EPA, Washington DC, United States, 3Johns Hopkins University, Health Policy & Management, Baltimore, MD, United States, 4University of California, Epidemiology and Biostatistics, San Francisco, CA, United States, 5Johns Hopkins University, Medicine, Epidemiology, and Health Policy & Management, Baltimore, MD, United States, 6Office of Policy, US EPA, Washington DC, United States. |
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| 3:15 PM–3:30 PM |
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Changing Complexion of Drug Safety Studies in Pregnancy in the Published Literature |
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Covington D1, Veley K1, McGee A2. 1PPD, Wilmington, NC, United States, 2UNCW, Wilmington, NC, United States. |
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| 3:30 PM–3:45 PM |
Break |
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| 3:45 PM–5:30 PM |
HOT TOPICS SYMPOSIUM – Grand Ballroom A |
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Neural Tube Defects Cluster in Washington State |
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Chairpersons: Richard H. Finnell, The University of Texas at Austin and Janee Gelineau-van Waes, Creighton University School of Medicine |
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| 3:45 PM–3:50 PM |
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Introduction |
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| 3:50 PM–4:00 PM |
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Finding the Cluster |
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Sara Barron |
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| 4:00 PM–4:15 PM |
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Approaches to Cluster Investigations of Birth Defects: Challenges and Opportunities |
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J. David Erickson, Centers for Disease Control and Prevention |
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| 4:15 PM–4:30 PM |
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Notes from the Field: Investigation of a Cluster of Neural Tube Defects — Central Washington, 2010–2013 |
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Mandy Stahre, Washington State Department of Health |
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| 4:30 PM–4:45 PM |
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Environmental/Occupational Exposures and NTDs on the Texas-Mexico Border |
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Mark Canfield, Texas Department of State Health Services |
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| 4:45 PM–5:00 PM |
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Tortillas and Toxins: Fumonisin Exposure as a Risk Factor for NTDs |
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Janee Gelineau-van Waes, Creighton University School of Medicine |
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| 5:00 PM–5:30 PM |
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Discussion |
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| 5:30 PM–7:30 PM |
TS/NBTS JOINT POSTER SESSION 1 AND EXHIBITS OPEN – Evergreen Ballroom |
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Society for Birth Defects Research and Prevention Posters: P1–P26
Chairpersons: Elise Madison Lewis, Charles River Laboratories and Terry C. Hrubec, E. Via Virginia College of Osteopathic Medicine
NBTS Posters: P01-P21 |
Click Here to Browse Posters
Poster Session 1
(Presenter designated by underlined author.)
P1
Toufaily MH1,2, Westgate M-N1,2, Holmes LB1,2. 1Medical Genetics, MassGeneral Hospital for Children, Boston, MA, United States, 2Department of Newborn Medicine, Brigham and Women’s Hospital, Boston, MA, United States. Club Foot Deformity: Associated Abnormalities
P2
Han J-Y, Kwack H-S, Choi J-S, Ahn H-K. Korean Motherisk Program, Cheil Hospital, Kwandong University School of Medicine, Seoul, Republic of Korea. Urinary Concentrations of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Women Self-Reporting Cigarette Smoking in the First Trimester of Pregnancy
P3
Stephens TD. Idaho State University, Pocatello, ID, United States. Unilateral, Postaxial, and/or Transverse Limb Defects and Thalidomide
P4
Poon S1,2, Carnevale A1,2, Kapur B1,2, Koren G1,2. 1Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada. Maternal Hair As a Biomarker to Assess Polybrominated Diphenyl Ether (PBDE) Exposure in Male Infants with Hypospadias
P5
Park JY, Senn T, Vigoren EM, Griffith WC, Lin YS, Faustman EM. University of Washington, Seattle, WA, United States. Method Development of Targeted LC/MS Screening Method for Pesticide Exposure
P6
Carmichael SL1, Yang W1, Roberts EM3, Kegley SE4, Padula AM1, Lammer EJ5, English PB2, Shaw GM1. 1Stanford University, Stanford, CA, United States, 2California Department of Public Health, Richmond, CA, United States, 3Public Health Institute, Oakland, CA, United States, 4Pesticide Research Institute, Berkeley, CA, United States, 5Children’s Hospital Oakland Research Institute, Oakland, CA, United States. Congenital Heart Defects and Residential Proximity to Agricultural Pesticide Applications in the San Joaquin Valley of California
P7
Carmichael SL1, Rasmussen SA2, Cunningham ML4, Ma C1, Browne ML5, Lammer EJ3, Shaw GM1. 1Stanford University, Stanford, CA, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States, 3Children’s Hospital Oakland Research Institute, Oakland, CA, United States, 4University of Washington, Seattle, WA, United States, 5New York State Department of Health, Albany, NY, United States. Craniosynostosis and Exposures Related to Thyroid Function
P8
Umpierre CC. University of Puerto Rico, Cayey, PR, United States. Possible Environmental Risk Factors for Neural Tube Defects among Puerto Rican Women from 2003–2005
P9
Boghossian N1, Sicko R2, Kay D2, Rigler S3, Yeung E1, Druschel C4, Romitti P5, Browne M4, Fan R1, Liu A1, Brody L6, Mills J1. 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 2Wadsworth Center, New York State Department of Health, Albany, NY, United States, 3Naval Medical Center Portsmouth, Portsmouth, VA, United States, 4Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 5University of Iowa, Iowa City, IA, United States, 6National Human Genome Research Institute, Bethesda, MD, United States. Rare Copy Number Variants in Urinary System and Reproductive Genes Implicated in Posterior Urethral Valves
P10
Di Bona KR1, Xu Y2, Keith J1, Bao Y2, Rasco JF1. 1Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, United States, 2Department of Chemical and Biological Engineering, Tuscaloosa, AL, United States. Morphological Changes and Increased Fetal Deaths Observed in CD-1 Mice after Exposure to Surface-Charged Iron Oxide Nanoparticles In Utero
P11
Williams AL, DeSesso JM. Exponent, Inc., Alexandria, VA, United States. Animal Behavior after Perinatal Chlorpyrifos Exposure is Not Autistic-Like
P12
Campbell MA1, Johnson PI2, Vesterinen HM2, Kim AN1, Koustas E3, Atchley DS2, Zeise L1, Sutton P2, Donald JM1, Woodruff TJ2. 1Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland and Sacramento, CA, United States, 2University of California San Francisco, Program on Reproductive Health and the Environment, Oakland, CA, United States, 3ORISE Postdoctoral Fellowship, US Environmental Protection Agency, Office of Policy, National Center for Environmental Economics, Washington DC, United States. Application of the Navigation Guide Method of Systematic Review to Assessing the Potential Developmental and Reproductive Hazards of Triclosan
P13
Shea CS1, Melin VE1, Hrubec TC1,2. 1VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States, 2Virginia College of Osteopathic Medicine, Virginia Campus, Blacksburg, VA, United States. Male and Female Exposures Both Contribute to Teratogenicity of QAC Disinfectants
P14
Mitchell AZ, Taschwer M, Nelson JR, Henwood S. Covance Laboratories Inc., Madison, WI, United States. Feasibility of Maternal and Embryonic Sample Collection during Organogenesis in Cynomolgus Monkeys (Macaca fascicularis)
P15
McCormick LA1, Dzubow RC2, Davis M2, Foos B2. 1Association of Schools and Programs of Public Health, Washington, DC, United States, 2Office of Children’s Health Protection, US Environmental Protection Agency, Washington, DC, United States. Children’s Health Risk Assessment at EPA and Its Implications for Policy Decisions and Identifying Data Gaps
P16
Wan H, Pan L, McPherson S, Mason S. WuXi AppTec (Suzhou) Co., Ltd., Suzhou, China. Investigation of Reproductive and Developmental Toxicity of Caffeine in Rats
P17
Enright BP1, Zhu Y2, Chao D2, Keller S2. 1AbbVie Inc., North Chicago, IL, United States, 2AbbVie Biotherapeutics Corp., Redwood City, CA, United States. Postimplantation Development in Pregnant Mice Administered an Anti-CD3 Antibody
P18
Balogun WG, Cobhams AE, Ishola AO, Fawoye GT, Akinola OB. University of Ilorin, Ilorin, Kwara, Nigeria. Histological and Biochemical Changes in the Prefrontal Cortex of Wistar Rats following Prenatal Exposure to Bitter Leaf
P19
Yin L, Yu X. University of Georgia, Athens, GA, United States. Bisphenol A (BPA) Affects the Spermatogenesis by Disrupting Gene Regulations in Glycomics
P20
Toot JD1, Gleason TR1, Edwards TR1, Moehle RM1, Loris SM1, Fisher SA2, Reho JJ2. 1WIL Research, Ashland, OH, United States, 2University of Maryland, Baltimore, Department of Medicine, Division of Cardiovascular Medicine, Baltimore, MD, United States. Maternal Changes in Microvascular Myosin Phosphatase Isoforms and Contractile Gene Expression in Surgical and Nonsurgical Models of Preeclampsia in the Sprague Dawley Rat
P21
Primakova I1, Lewis E2, Pouliot L1, Barbeau S1, Robinson K1. 1Charles River Laboratories, Preclinical Services Montreal, Senneville, QC, Canada, 2Charles River Laboratories, Preclinical Services Horsham, Horsham, PA, United States. Embryo-Fetal Development Historical Control Data in Wistar Han IGS Rats
P22
Melin VE1, Hrubec TC1,2. 1VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States. Toxicity of Quaternary Ammonium Compounds on Male Mouse Reproductive Function
P23
Stump DG1, Obrecht JC1, Foster KC1, Dukles CA1, Cedeno DA1, Coder PS2. 1WIL Research, Ashland, OH, United States, 2Battelle, Columbus, OH, United States. A Rat Model for Assessment of Pseudopregnancy
P24
Mikelson C1, DiRe L3,4, Troisi J5, Adair D6, Salafia C2,3, Richards S1. 1University of Tennessee at Chattanooga, Chattanooga, TN, United States, 2Placental Analytics, LLC, Larchmont, NY, United States, 3NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY, United States, 4St. Johns University, Queens, NY, United States, 5Laboratorio Chimico Merceologico, Chamber of Commerce, Naples, Italy, 6Regional Obstetrical Consultants, Chattanooga, TN, United States. Perinatal Effects of Gestational Metals Exposures: Evidence for Gender-Specific Fetal Toxicity
P25
Powles-Glover NS, Stewart J. AstraZeneca, DSM, Mereside, Alderley Edge, Cheshire, United Kingdom. Blood Capillary Microsampling in Suckling and Weaned Rats, Effect on Toxicological Endpoints, and Reduction in and/or Elimination of the Need for Satellite Pups
P26
Coles CD, Kable JA, Lynch ME. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States. Prenatal Tobacco Exposure and Behavior Regulation at 24 Months: Child Language and Maternal Psychological Symptoms as Moderators
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7:30 PM–10:00 PM |
TS/MARTA STUDENT CAREER EVENT – Juniper |
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