Sunday, June 29, 2014 |
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| 7:00 AM–8:00 AM |
DINE WITH A TERATOLOGY AMBASSADOR – Juniper
(Advance Signup Required) |
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| 7:00 AM–8:00 AM |
SCIENCE COMMITTEE MEETING – Evergreen Ballroom G |
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| 7:00 AM–6:00 PM |
REGISTRATION – Grand Ballroom Foyer |
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7:00 AM–6:00 PM |
SPEAKER READY ROOM OPEN – Grand Ballroom Foyer |
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8:00 AM–8:15 AM |
PRESIDENT’S WELCOME – Grand Ballroom E |
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Elaine Z. Francis, Sandcastle Toxicology Associates |
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8:15 AM–9:00 AM |
JOSEF WARKANY LECTURE (JOINT WITH NBTS) – Grand Ballroom E |
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Teratology v2.0: Building a Path Forward (L1) |
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Chairperson: Elaine Z. Francis, Sandcastle Toxicology Associates |
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Thomas B. Knudsen, National Center for Computational Toxicology, US EPA |
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9:00 AM–12:00 Noon |
STUDENT/POSTDOCTORAL FELLOW PLATFORM SESSION 1 – Grand Ballroom E |
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Organized by the Student Affairs Committee
Chairperson: Christina M. Carruthers, Forest Research Institute |
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| 9:00 AM–9:15 AM |
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Introduction |
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Christina M. Carruthers, Forest Research Institute |
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| 9:15 AM–9:30 AM |
1 |
Antidepressant Use during Pregnancy and Risk of Autism Spectrum Disorders in Children above or beyond of Genetic Background |
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Boukhris T1,2, Sheehy O2, Berard A1,2. 1Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, 2Research Center, CHU- Sainte-Justine, Montreal, QC, Canada. |
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| 9:30 AM–9:45 AM |
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The Neurobehavioral Consequences of Chronic Atrazine Exposure during Early Development in Male and Female Sprague-Dawley Rats |
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Walters J, Burroughs R, Hunt S, Harvey E, Baker L. Western Michigan University, Kalamazoo, MI, United States. |
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| 9:45 AM–10:00 AM |
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Medical History Predicts Phenotypic Differences in Autism Spectrum Disorder |
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Wenger TL, Parish-Morris J, DePolo L, Yerys BE, Schultz RT. Children's Hospital of Philadelphia, Philadelphia, PA, United States. |
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| 10:00 AM–10:15 AM |
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Fumonsin B1-Induced NTDs: Is Nuclear Sa1P to Blame? |
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Gardner NM1, Sachs AJ1, Riley RT2, Maddox JR1, Gelineau-van Waes J1. 1Dept. of Pharmacology, Creighton University-School of Medicine, Omaha, NE, United States, 2Toxicology and Mycotoxin Research Unit, USDA-ARS, Athens, GA, United States. |
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| 10:15 AM–10:30 AM |
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Defining a Transcriptomic Signature for Developmental Toxicity Prediction in the Zebrafish Embryo |
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Hermsen SAB1,2, Pronk TE1,2, van den Brandhof EJ1, van der Ven LTM1, Piersma AH1,3. 1RIVM, Bilthoven, Netherlands, 2Maastricht University, Maastricht, Netherlands, 3Utrecht University, Utrecht, Netherlands. |
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| 10:30 AM–10:45 AM |
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Break |
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| 10:45 AM–11:00 AM |
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Cellular Stress, Excess Apoptosis, and the Effect of Metformin on a Mouse Model of Type 2 Diabetic Embryopathy |
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Wu Y, Wang F, Yang P. University of Maryland, Baltimore, MD, United States. |
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| 11:00 AM–11:15 AM |
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Class-Specific Histone Deacetylase (HDAC) Inhibitors Have Differential Adverse Effects on Chondrogenesis and Early Osteogenesis in Murine Limb Buds In Vitro |
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Paradis FH, Hales BF. McGill University, Montreal, QC, Canada. |
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| 11:15 AM–11:30 AM |
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Assessing Early Developmental and Pubertal Effects in CD-1 Mice Following In Utero Exposure to Bisphenol (BP) Analogs |
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Robinson D1,2, Fenton S2. 1University of North Carolina, Chapel Hill, Chapel Hill, NC, United States, 2NTP Laboratory Branch, NIEHS, Research Triangle Park, NC, United States. |
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| 11:30 AM–11:45 AM |
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Valproic Acid-Induced Alterations in CBP/p300 Regulation in P19 Embryonal Carcinoma Cells |
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Lamparter CL1, Winn LM1,2. 1Queen's University, Department of Biomedical and Molecular Sciences, Kingston, ON, Canada, 2Queen's University, School of Environmental Studies, Kingston, ON, Canada. |
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| 11:45 AM–12:00 Noon |
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Comparing PBDE Effects across Human Embryonic and Placental In Vitro Models |
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Robinson JF, Larocque N, Kapidzic M, McMaster MT, Fisher SJ. University of California, San Francisco, San Francisco, CA, United States. |
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12:00 Noon–1:30 PM |
LUNCH ON YOUR OWN |
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12:00 Noon–1:30 PM |
2015 PROGRAM COMMITTEE MEETING – Laurel |
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| 12:00 Noon–1:30 PM |
STUDENT AND POSTDOCTORAL LUNCH WORKSHOP – Grand Ballroom A
(Advance Registration Required) |
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Building a Successful Career in Developmental and Reproductive Toxicology: Part 1 (W1) |
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Chairpersons: Christine P. Curran, Northern Kentucky University and Jeffery H. Charlap, WIL Research |
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| 12:00 Noon–12:15 PM |
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Introduction |
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| 12:15 PM–12:35 PM |
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Writing Well: From Cover Letters to Major Grants |
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Christine P. Curran, Northern Kentucky University |
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| 12:35 PM–12:55 PM |
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Tips from the Top: Getting Published in High-Impact Journals |
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George P. Daston, Birth Defects Research Part B Editor and Michel Vekemans, Birth Defects Research Part A Editor |
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| 12:55 PM–1:15 PM |
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Finding the Perfect Match: Building Successful Mentor-Mentee Relationships |
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Mary Alice Smith, University of Georgia |
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| 1:15 PM–1:30 PM |
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Panel Discussion |
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| 12:00 Noon–1:30 PM |
F. CLARKE FRASER AND SERVICE AWARDS COMMITTEE MEETING – Evergreen Ballroom G |
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1:30 PM–2:00 PM |
F. CLARKE FRASER NEW INVESTIGATOR AWARD – Grand Ballroom E |
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From Computational Approaches to an Alternative Animal Model and Epidemiology: Building a Fulfilling Research Career (L2) |
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Chairperson: Robert G. Ellis-Hutchings, The Dow Chemical Company |
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Lecturer: Julia M. Gohlke, University of Alabama, Birmingham |
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2:00 PM–2:30 PM |
JAMES G. WILSON PUBLICATION AWARD – Grand Ballroom E |
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Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture |
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Chairperson: L. David Wise |
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Lecturer: Lorraine Posobiec, GlaxoSmithKline |
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2:30 PM–5:30 PM |
ILSI HESI SYMPOSIUM – Grand Ballroom E |
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Cross-Industry Data Survey of the Value of Rabbit Developmental
Toxicity Data in the Risk Assessment for Pharmaceutics |
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Chairpersons: Alan M. Hoberman, Charles River; Aldert H. Piersma, National Institute for Public Health and the Environment (RIVM); and Jane Stewart, AstraZeneca Pharmaceuticals |
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| 2:30 PM–3:00 PM |
S1 |
ICH Workshop Origins of the Survey |
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Jane Stewart, AstraZeneca Pharmaceuticals |
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| 3:00 PM–3:30 PM |
S2 |
An Analysis of Rat and Rabbit Developmental Toxicity Studies for Pharmaceuticals: The Scientific Background |
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Aldert H. Piersma, National Institute for Public Health (RIVM) |
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| 3:30 PM–3:45 PM |
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Break |
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| 3:45 PM–4:15 PM |
S3 |
A Comprehensive Data Survey of the Relative Value of Rat Versus Rabbit Developmental Toxicity Data in the Risk Assessment for Pharmaceuticals: Presentation of Results |
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Peter Theunissen, National Institute for Public Health (RIVM) and University of Applied Sciences Utrecht and Aldert H. Piersma, National Institute for Public Health (RIVM) |
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| 4:15 PM–4:45 PM |
S4 |
Industry Perspective: What Are the Implications to Industry of Changing the Default Paradigm of Two-Species Developmental Toxicity Testing? |
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Alan M. Hoberman, Charles River Laboratories, Preclinical Services |
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| 4:45 PM–5:15 PM |
S5 |
Regulatory Perspective: How Might the Risk Assessment of Novel Drugs and Regulatory Decisions Profit from the Results of This Survey? |
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Sonja Beken, Federal Agency for Medicines and Health Products, Belgium |
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| 5:15 PM–5:30 PM |
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Discussion |
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| 2:30 PM–5:30 PM |
TS/NBTS JOINT SYMPOSIUM – Grand Ballroom I |
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National Children’s Study |
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Chairperson: Elaine M. Faustman, University of Washington and Richard K. Miller, University of Rochester |
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| 2:30 PM–2:55 PM |
S6 |
An Integrated Framework for Linking Exposure and Phenotypic Data in the National Children’s Study |
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Steven Hirschfeld, National Children's Study |
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| 2:55 PM–3:20 PM |
S7 |
Streamlining the Diagnosis of Autism Spectrum Disorder for the National Children's Study |
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Wendy Stone, University of Washington |
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| 3:20 PM–3:45 PM |
S8 |
Results of Whole-Genome Analysis from National Children’s Study (NCS) |
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Elaine M. Faustman, University of Washington |
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| 3:45 PM–4:00 PM |
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Break |
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| 4:00 PM–4:25 PM |
S9 |
Novel Insights on the Molecular Targets of Environmental Exposures during Pregnancy Using Placental Multi’omics Data Integration in the National Children’s Study (NCS) |
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Kjersti M. Aagaard, Baylor College of Medicine |
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| 4:25 PM–4:50 PM |
S10 |
Environmental Exposures during Pregnancy: US National Children's Study Formative Research Investigation |
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Richard K. Miller, University of Rochester |
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| 4:50 PM–5:15 PM |
S11 |
Integration of Biological Cortisol Concentrations and Stress Questionnaires As a Marker of Maternal Stress |
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Shirley A. Beresford and Marissa N. Smith, Fred Hutchinson Cancer Research Center and University of Washington |
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| 5:15 PM–5:30 PM |
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Discussion |
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5:30 PM–7:30 PM |
TS/NBTS JOINT WELCOME RECEPTION, SILENT AUCTION, AND EXHIBITS OPEN – Evergreen Ballroom |
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| 7:30 PM–8:30 PM |
MEMBERSHIP COMMITTEE MEETING – Evergreen Ballroom G |
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