Poster Session 2
(Presenter designated by underlined author.)
Clinical Teratology
P30 Antenatal Suspicion and Postnatal Presentation of Scimitar Syndrome
Toufaily MH1,2, Roberts DJ3, Westgate MN1,2, Holmes LB1,2. 1Medical Genetics Unit, MassGeneral Hospital for Children, Boston, MA, United States, 2Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA, United States, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, United States.
P31 Urethral Atresia: Prenatal Diagnosis, Clinical Presentation, and Outcome
Toufaily MH1,2, Roberts DJ3, Westgate MN1,2, Holmes LB1,2. 1Medical Genetics Unit, MassGeneral Hospital for Children, Boston, MA, United States, 2Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA, United States, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, United States.
P32 A KAP Survey amongst Health Care Professionals on Birth Defects in Grenada
Fakoya FA, Ilesanmi A, Wade A, Hegamin-Younger C. St. George’s University, St. George’s, Grenada.
P33 Describing the Global Burden of Neural Tube Defects: A Systematic Literature Review
Zaganjor I1, Sekkarie A1, Tsang BL1, Williams J1, Razzaghi H2, Mulinare J2, Sniezek JE1, Cannon MJ1, Rosenthal J1. 1CDC National Center on Birth Defects and Developmental Disabilities, Atlanta, GA, United States, 2Carter Consulting Inc., Atlanta, GA, United States.
P34 Folic Acid Use in Women before and during Pregnancy: A United Kingdom Primary Care Prescribing Study
Ban L, Fleming KM, Fiaschi L, Tata LJ. University of Nottingham, Nottingham, United Kingdom.
P35 The Role of Folic Acid in the Prevention of Neural Tube Defects
Vereczkey A1, Czeizel AE2. 1Versys Clinics Human Reproduction Institute, Budapest, Hungary, 2Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary.
P36 Birth Outcomes and Risk or Protective Factors of Ventricular Septal Defects during Pregnancy
Vereczkey A1, Czeizel AE2. 1Versys Clinics Human Reproduction Institute, Budapest, Hungary, 2Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary.
P37 Birth Defects and Growth Restriction in Term and Late Preterm Singletons with Cerebral Palsy or Neonatal Death
McIntyre S1,3, Blair E3, Badawi N2,1, Nelson KB4,5. 1Cerebral Palsy Alliance, Sydney, Australia, 2University of Sydney, Sydney, Australia, 3Telethon Kids Institute, Perth, Australia, 4Children’s National Medical Centre, Washington, DC, United States, 5NINDS/NIH, Bethesda, MD, United States.
P38 Possible Infant Exposure Pathways to Cronobacter Species in Homes
Chan MY1,4, Zambrana J1,4, McIntosh TG1,4, McKenzie M1,4, Williams A1,4, Smith MA1,4. 1Department of Environmental Health Science, Athens, GA, United States, 2Center for Food Safety, Athens, GA, United States, 3Regenerative Bioscience Center, Athens, GA, United States, 4University of Georgia, Athens, GA, United States.
Environmental Hazard Identification and Risk Assessment
P39 Developmental Toxicity Study of Aluminum Oxide Nanoparticles by Oral Administration in Rats
Lee J1, Yu W-J1, Song J1, Sung C1, Lee S-Y1, Park J-D1, Jeong EJ1, Chung M-K1, Park K2. 1Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea, 2College of Pharmacy, Dongduk Women’s University, Seoul, Republic of Korea.
P40 Gene Expression Changes in the Testes and Prostate from Postnatal Day 30 Sprague-Dawley Rats Dosed Perinatally with Oxybenzone-Preliminary Study
Nakamura N1, Inselman AL1, Han T1, Fuscoe JC1, Harrouk W2, McIntyre B3, Foster PM3, Hansen DK1. 1National Center for Toxicological Research, US FDA, Jefferson, AR, United States, 2Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, United States, 3National Toxicology Program, Research Triangle Park, NC, United States.
P41 Reproductive and Systemic Toxicity Analysis of LMFP, a Lithium-Ion Battery Component
Johnson KJ, Zablotny CL, Stebbins KE, Andrus AK. The Dow Chemical Company, Midland, MI, United States.
P42 The Role of Fertility Restoration in the Maintenance of Antioxidant Enzymes after Transient Heat Stress in Mice
Chu SB, Lin C, Park SG, Yon J-M, Gwon LW, Lee BJ, Yun YW, Nam S-Y. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
P43 Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Interferes with Skeletal Ossification
Yan H1, Tung EWY2, Lefèvre PLC1, Berger RG1, Paradis FH1, Wade MG2, Robaire B1,3, Hales BF1. 1Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada, 2Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada, 3Department of Obstetrics and Gynecology, McGill University, Montréal, QC, Canada.
P44 Harm Reduction Tobacco Induces Bone Teratogenicity via Oxidative Stress
Sparks NRL, zur Nieden NI. Environmental Toxicology Graduate Program and Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA, United States.
P45 Maternal Tobacco Use As a Risk Factor for Small for Gestational Age (SGA) is a Third-Trimester Effect
Afari-Dwamena NA1,2, Ferdosi H1,2, Dissen E1, Li J1,4, Chen R3, Feinleib M5, Lamm SH1,5,6, Polifka J7. 1Consultants in Epidemiology and Occupational Health, LLC, Washington, DC, United States, 2George Washington University, Milken Institute School of Public Health, Washington, DC, United States, 3Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Georgetown University, Centers for New Designs in Learning and Scholarships, Washington, DC, United States, 5Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United States, 6Georgetown University School of Medicine, Pediatrics, Washington, DC, United States, 7Department of Pediatrics, University of Washington, Seattle, WA, United States.
P46 Are Residents of Coal Mining Counties More Likely to Have Infants with Birth Defects?
Lamm SH1,2,3, Afari-Dwamena NA1, Ferdosi H1,4, Qian L1,5. 1Center for Epidemiology and Global Health (CEOH), Washington, DC, United States, 2Department of Health Policy and Management, Johns Hopkins University-Bloomberg School of Public Health, Baltimore, MD, United States, 3Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, United States, 4Milken Institute School of Public Health, George Washington University, Washington, DC, United States, 5Department of Mathematics and Statistics, American University, Washington, DC, United States.
P47 Associations between Maternal Periconceptional Exposure to Environmental Tobacco Smoke and Major Noncardiac Birth Defects
Canfield MA1, Hoyt AT1, Romitti PA2, Botto LD3, Anderka MT4, Krikov S3, Tarpey M1, Feldkamp ML3. 1Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 2Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, United States, 3Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, United States, 4Massachusetts Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA, United States.
P48 Carbon Monoxide Exposure and Detection in Pregnancy: Case Studies from the California Poison Control System
Dodd-Butera T1,2, Beaman M1, Flores K2,3, Broderick Pritty M4, Chambers C3, Clark RF4. 1California State University, San Bernardino, College of Natural Sciences, San Bernardino, CA, United States, 2San Diego State University, Graduate School of Public Health, San Diego, CA, United States, 3University of California, San Diego, Department of Pediatrics, La Jolla, CA, United States, 4California Poison Control System, San Diego Division, San Diego, CA, United States.
P49 Sensitivity of Air Pollution Exposure Estimates to Exposure Assessment Decisions: Maternal Exposures to Ambient PM2.5 and Benzene
Tanner JP1, Salemi JL2, Yu H1, Jordan MM3, DuClos C3, Cavicchia P3, Correia J3, Watkins SM3, Kirby RS1, Stuart AL1. 1University of South Florida, Tampa, FL, United States, 2Baylor College of Medicine, Houston, TX, United States, 3Florida Department of Health, Tallahassee, FL, United States.
P50 Associations between Exposure to Ambient Benzene and PM2.5 during Pregnancy and the Risk of Selected Birth Defects in Offspring
Salemi JL2, Tanner JP1, Stuart AL1, Jordan MM3, DuClos C3, Cavicchia P3, Correia J3, Watkins SM3, Kirby RS1. 1University of South Florida, Tampa, FL, United States, 2Baylor College of Medicine, Houston, TX, United States, 3Florida Department of Health, Tallahassee, FL, United States.
P51 Impact of In Utero Exposure of Lead (Pb), Arsenic (As), and Zinc (Zn) on the Neurodevelopment of Young Children from Birth to 36 Months of Age: A Birth Cohort Study in Chitwan Valley, Nepal
Parajuli RP1, Umezaki M2, Fujiwara T3, Watanabe C2. 1The Environmental Health Sciences Lab, McGill University, Montréal, QC, Canada, 2Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo Ku, Tokyo, Japan, 3Department of Social Medicine National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan.
P52 Contribution of Arsenic and Lead in Residential Soils to the Risk of Major Congenital Anomalies in England
Othman F1, Gibson JE1, Ander L2, Cave M2, Tata LJ1. 1University of Nottingham, Epidemiology and Public Health, Nottingham, United Kingdom, 2British Geological Survey, Environmental Science Centre, Keyworth, United Kingdom.
P53 Maternal Occupational Exposure to Ionizing Radiation and Major Structural Birth Defects
Lim H1, Agopian AJ2, Whitehead LW2, Beasley CW3, Langlois PH4, Emery RJ2, Waller DK2. 1National Cancer Institute, Bethesda, MD, United States, 2University of Texas School of Public Health, Houston, TX, United States, 3University of Texas School of Medicine, Houston, TX, United States, 4Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States.
P54 Residential Agricultural Pesticide Exposures and Risks of Selected Birth Defects among Offspring in the San Joaquin Valley of California
Carmichael SL1, Yang W1, Roberts E2, Kegley SE3, Brown TJ3, Lammer EJ5, English PB4, Shaw GM1. 1Stanford University, Stanford, CA, United States, 2Public Health Institute, Oakland, CA, United States, 3Pesticide Research Institute, Berkeley, CA, United States, 4California Department of Public Health, Richmond, CA, United States, 5Children’s Hospital Oakland Research Institute, Oakland, CA, United States.
P55 Diet Quality, Obesity, and Birth Defects
Carmichael SL1, Yang W1, Gilboa S2, Ailes E2, Correa A3, Botto L4, Feldkamp M4, Shaw GM1. 1Stanford University, Stanford, CA, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States, 3University of Mississippi Medical Center, Jackson, MS, United States, 4University of Utah School of Medicine, Salt Lake City, UT, United States.
P56 Development of a Noncancer Toxicity Criterion Using Developmental Toxicity Data As the Most Sensitive Endpoint in Estimating Health Risk(s) from TEG-Contaminated Coffee
Hixon ML, Mayfield D, Peterson MK, Dube E, Beyer L. Gradient, Cambridge, MA, United States.
Experimental Models
P57 Preliminary Assessment of F344-Sasco Rats As a Developmental Toxicity Research Model for Effects on Pregnancy Maintenance and Eye Malformations: Pilot Study with Trichloroacetic Acid
Narotsky MG1, Best DS1, Rubin Z2, Winters BR3. 1US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, ORD, Research Triangle Park, NC, United States, 2University of North Carolina, College of Arts and Sciences, Chapel Hill, NC, United States, 3University of North Carolina, Biological and Biomedical Sciences Program, Chapel Hill, NC, United States.
P58 Modification of the Astroff Frozen Head Evaluation for Rat Fetuses
Seethala R, Olitan TA, Thompson KE. Bristol-Myers Squibb Company, New Brunswick, NJ, United States.
P59 Investigating Additional Differentiation Endpoints in the Mouse Embryonic Stem Cell Test
Inselman AL1, Hansen DK1, Harrouk W2, Fisher JE2, Tassinari MS2, Nolen GT1, Merry GE1, Chen X1. 1National Center for Toxicological Research, US FDA, Jefferson, AR, United States, 2Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, United States.
P60 Timing of Zebrafish Developmental Toxicity Assessments: Four versus Five Days Post Fertilization
Gurrola-Gal MC, Brannen KC. Charles River Laboratories, Horsham, PA, United States.
P61 Comparison of Human Neural Progenitor and Differentiated Human Neuronal Cells for In Vitro Tests of Neurotoxicity
Amosu M1, Wallace S2, Majumder A2, Bian X1, Lu K1, Stice S1,2, Smith MA1. 1University of Georgia, Athens, GA, United States, 2ArunA Biomedical, Inc., Athens, GA, United States.
P62 Anchoring a Dynamic In Vitro Model of Human Neuronal Differentiation to Key Processes of Brain Development In Vivo
Wegner SH, Stanaway IB, Hermsen SAB, Kim HY, Park JY, Griffith WC, Hong S, Faustman EM. University of Washington, Seattle, WA, United States.
P63 In Silico Prediction of Teratogenicity: A Novel Semiautomated Mechanistic Expert Call Dataset Analysis Approach
Plante JP, Fowkes A, Surfraz MB. Lhasa Limited, Leeds, United Kingdom.
P64 Atlas for Skeletal Development in Cynomolgus Monkey Fetuses
Da Silva M, Dauzat C, Spézia F, Singh P, Foulon O, Forster R. CiToxLAB France, Evreux, France.
P65 Wistar Han IGS® Rats and CD®-IGS Rats: Comparison of Development and Behavioral Data
Barbeau S, Martin A, Primakova I, Pouliot L, Adamo M, Robinson K. Charles River Laboratories, Senneville, QC, Canada.
P66 Measurements of Growth in Nonrodent Juvenile Toxicology Studies
Robinson K, Adamo M, Martin A, Samadafan R. Charles River Laboratories, Senneville, QC, Canada.
P67 Postnatal Cardiovascular Assessments in Nonclinical Pediatric Studies in Juvenile Beagles Using Jacketed External Telemetry
Adamo M, Matheson R, Norton K, Robinson K. Charles River Laboratories, Montréal, QC, Canada.
P68 Parenteral Dosing Routes in Juvenile Mice: Comparison of Growth and Development to Orally Dosed and Untreated Juvenile Mice
Martin A1, Felx M1, Lewis E2, Pouliot L1, Robinson K1. 1Charles River Laboratories, Senneville, QC, Canada, 2Charles River Laboratories, Horsham, PA, United States.
P69 A Qualification Intravenous Infusion Study in Juvenile Sprague-Dawley Rats
Gordon C, Galicia A, Maghezzi MS. CiToxLAB North America, Laval, QC, Canada.
P70 Control Data from Sprague-Dawley Rat Juvenile Toxicity Studies: Part 1
Parker RM, Williams D, Baxter GE. Huntingdon Life Sciences, East Millstone NJ, United States.
P71 Control Data from Sprague-Dawley Rat Juvenile Toxicity Studies: Part 2
Baxter GE, Williams D, Williams RM. Huntingdon Life Sciences, East Millstone NJ, United States.
P72 Development of an Epaxial Intramuscular Injection Technique in Juvenile Rats
Baxter GE, Croft L, Callahan J, Parker RM. Huntingdon Life Sciences, East Millstone, NJ, United States.
P73 The Extended One-Generation Reproductive Toxicity Study (EOGRTS): An Update on Current European Legislation and Considerations for Implementation
Beekhuijzen MEW1, Marsden E2, Sloter ED3. 1WIL Research Europe, Den Bosch, Netherlands, 2WIL Research Europe, Lyon, France, 3WIL Research US, Ashland, OH, United States.
P74 Weight of Evidence Considerations for Determining the Necessity of a Developmental Immunotoxicity (DIT) Cohort in an EOGRTS (OECD 443) within the REACH Framework
Foreman JE, North CM, Goyak KO, Ketelslegers H, Minsavage GD. ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, United States.