Program
Meeting Agenda
Society for Birth Defects Research and Prevention 2019 Annual Meeting—Sea Changes in Birth Defects Research and Prevention
Only sessions designated with
are eligible for Continuing Medical Education credit.
P1
Lachenauer ER1, Stabler SP2, Field MS1, Stover PJ3.
1Cornell University, Ithaca, NY, United States, 2University
of Colorado, Aurora, CO, United States, 3Texas A&M University, College
Station, TX, United States. p53 Disruption Increases Uracil Accumulation in DNA and Leads to Folic Acid Nonresponsive Neural
Tube Defects in Mice
P2
Harrison DB, Wang L, Gaitan
A, Stamen MN, Lane SR, Bultman JD, Coder PS. Charles River Laboratories,
Ashland, OH, United States. The
Use of Female Mice Implanted with Vascular Access Buttons (VABs) in
Reproduction Studies
P3
Jia Y1,2,3, Jiang J1,2,3, Yang Y1,2,3, Chong L1,2,3,
Mao X1,2,3, Zhou L1,2,3, Sun Z1,2,3. 1Shanghai
Institute of Planned Parenthood Research, National Evaluation Center for Toxicology
of Fertility Regulating Drugs, 2National Population and Family Planning
Key Laboratory of Contraceptive Drugs and Devices, 3Reproductive and
Developmental Research Institute, Fudan University, Shanghai, Shanghai, China. Background
Data of SD Rats in Embryo-Fetal Development Toxicity Study
P4
Dodd-Butera T1,2, Beaman M2, Li H3. 1Azusa Pacific
University, San Diego, CA, United States, 2CSU San Bernardino, San Bernardino,
CA, United States, 3Azusa Pacific University, Azusa, CA, United States.
Poisoning and Pregnancy: A Review from the National Poison Data System
P5
Chen H1, Williams KE1, Kapidzic M1, Kwan E1,
Aburajab R1, Hunter CL2, Fisher SJ1, Robinson JF1.
1University of California–San Francisco, San Francisco, CA, United States, 2AB
SCIEX, Redwood City, CA, United States. Brominated
Flame Retardant BDE-47 Induces Proteomic Alterations in Primary Human Villous
Cytotrophoblasts
P6
Derrick DJ1, Wolton K2, Currie R2, Tindall MJ1.
1Department of Mathematics and Statistics, University of Reading, Reading,
Berkshire, United Kingdom, 2Syngenta, Jealott’s Hill International Research
Centre, Bracknell, Berkshire, United Kingdom. A Mathematical Model of the
Role of Aggregation in Sonic Hedgehog Signalling
P7
Cortés OD, López Serna N. Autonomous University of
Nuevo Leon, Monterrey, Nuevo Leon, Mexico. Facial Dysmorphology As an
Indicator of Organ Malformation: A Report of Two Cases
P8
Cheng V, Reddam A, Dasgupta S, Volz DC. University
of California–Riverside,
Riverside, CA, United States. PPARγ Agonist-Induced Disruption of
Dorsoventral Patterning in Zebrafish
P9
Sheehy O1, Zhao J-P1, Berard A1,2. 1CHU Sainte-Justine Research Center, Montréal, QC, Canada, 2Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada. Incident Exposure to Benzodiazepine in Early Pregnancy and the Risk of Spontaneous Abortion
P10
Berard A1,2,3, Abbas-Chorfa F4, Kassai B3,5,6, Vial T3,5,7,
Nguyen K3,5,6, Sheehy O1, Schott A8,9. 1Research
Center, CHU Sainte-Justine, Montréal, QC, Canada, 2Faculty of Pharmacy,
University of Montréal, Montréal, QC, Canada, 3EPICIME-CIC 1407 Lyon,
Inserm, Pharmacotoxicology Department, CHU-Lyon, Bron, France, 4Hospices
Civils de Lyon, Service de biostatistique-bioinformatique, Pôle Santé Publique,
Lyon, France, 5University of Lyon 1, Lyon, France, 6Laboratoire
de Biométrie et Biologie Evolutive, University of Lyon 1, CNRS, Villeurbanne, France,
7Service Hospitalo-Universitaire de Pharmacotoxicologie, CHU-Lyon, Lyon,
France, 8Hospices Civils de Lyon, Pôle de Santé Publique, Lyon, France,
9Université Lyon Claude Bernard Lyon 1, Lyon, France. The French
Pregnancy Cohort: Prevalence and Trend of Medication Use during Pregnancy in
the French Population
P11
Knudsen TB1, Zurlinden TJ2, Saili KS2, Baker NC3.
1US EPA/ORD/NCCT, Research Triangle Park, NC, United States, 2USEPA/ORD/NCCT,
Research Triangle Park, NC, United States, 3Leidos, Research Triangle
Park, NC, United States. ToxCast Embryonic Stem Cell (H9) Profiling for
Predicting Developmental Toxicity
P12
Moris N1, Turner DA1, Schroeder J2, Baranowski A1,
Anlas K3, Martinez Arias A1. 1Department
of Genetics, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom,
2University of Heidelberg, Heidelberg, Baden-Württemberg, Germany, 3EMBL,
Barcelona, Barcelona, Spain. Gastruloids: An Embryonic Stem Cell-Based In Vitro Model of Human Development
P13
Racz PI, Brandsma I, Zwetsloot T, Hartvelt S, Hendriks
G. Toxys BV. Leiden, South-Holland, The Netherlands. Validation of a
Novel Human Stem Cell-Based Gene Expression Assay for In Vitro DART Assessment
P14
Silva MH1, Koshlukova S1, Rubin A1, Lohstroh P1,
Kalashnikova A1, Kwok E1, DuTeaux S1, Verder-Carlos
M2. 1Human Health Assessment Branch, Department of
Pesticide Regulation, California EPA, Sacramento, CA, United States, 2Department
of Pesticide Regulation, California EPA, Sacramento, CA, United States. Hazard
Identification for the Herbicide Propyzamide
P15
Marsden E1, Vignand P1, Loheac E2, Briffaux J-P1.
1Charles River Laboratories France Safety Assessment SAS, Saint-Germain-Nuelles,
Rhone-Alpes, France, 2Charles River Laboratories France, Saint-Germain-Nuelles,
Rhone-Alpes, France. Method Development for Intrauterine Administration of a
Contrast Agent in the Rat for a Safety Evaluation Including Developmental and
Reproductive Toxicology Endpoints
P16
Lee J1,2, Yu W-J1, Choi S-J3, Jeong J-S1, Kim
SY1, Shin Y-J1, Kim W4, Lee K3,5, Lee
S-H3, Jeong EJ1, Nam S-Y2. 1Developmental
and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Youseong-gu,
Daejeon, The Republic of Korea, 2College of Veterinary Medicine, Chungbuk
National University, Cheongju, Chungcheongbuk-do, The Republic of Korea, 3Inhalation
Toxicology Research Group, Korea Institute of Toxicology, Jeongeup, Jeollabuk-do,
The Republic of Korea, 4Toxicological Pathology Research Group, Korea
Institute of Toxicology, Youseong-gu, Daejeon, The Republic of Korea, 5Department
of Human and Environmental Toxicology, University of Science & Technology, Youseong-gu,
Daejeon, The Republic of Korea. Polyhexamethylene Guanidine Phosphate
Inhalation Exposure during the Pregnancy in Rats: Effects on Postnatal
Development of Offspring and Maternal Functions
P17
Viens L1, Fleck-Derderian
S2, Baez-Santiago M3, Oduyebo T4, Broussard
C4, Meaney-Delman D4. 1Chickasaw Nation
Industries, Inc., Norman, OK, United States, 2Oak Ridge Institute for
Science and Education, Oak Ridge, TN, United States, 3Eagle Medical Services,
San Antonio, TX, United States, 4Centers for Disease Control and Prevention,
Atlanta, GA, United States. Congenital Zika Syndrome: A Systematic Review of
the Role of Prenatal Ultrasound and Amniocentesis
P18
Nalbandyan M1, Howley MM1, Cunniff CM2, Romitti PA3,
Browne ML1. 1Congenital Malformations Registry, New
York State Department of Health, Albany, NY, United States, 2Division
of Medical Genetics, Department of Pediatrics, New York-Presbyterian Hospital/Weill
Cornell Medicine, New York, NY, United States, 3Department of Epidemiology,
College of Public Health, University of Iowa, Iowa City, IA, United States. Descriptive
and Risk Factor Analysis of Sacral Agenesis: National Birth Defects Prevention
Study, 1997–2011
P19
Cho SJ, Getschel M, Hort M, Peterson K. Minnesota
Department of Health, St. Paul, MN, United States. Lessons from Craniosynostosis Ascertainment Using
2015–2017 Birth Cohorts in Minnesota
P20
Sowunmi S, Eckert V, Olney R. California Department
of Public Health, Richmond, CA, United States. Assessing the Utility of
Public Health Laboratory-Reported Clinical Data for Use in Extended Zika Birth
Defects Surveillance in California
P21
Shumate CJ1, Hoyt AT1, Tarpey M1, Canfield MA1,
Lopez KN2. 1Texas Department of State Health Services,
Birth Defects Epidemiology and Surveillance Branch, Austin, TX, United States, 2Division
of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine,
Houston, TX, United States. Survival of Texas Heterotaxy Cases from Birth to
Ten-Years
P22
Hoyt AT1, Ramadhani T2, Shumate CJ1,
Canfield MA1, Le M1, Scheuerle AE3.
1Birth Defects Epidemiology and Surveillance Branch, Texas Department
of State Health Services, Austin, TX, United States, 2Health and Human
Services, Austin, TX, United States, 3University of Texas Southwestern
Medical Center, Dallas, TX, United States. Acculturation and Selected Birth
Defects Among Non-Hispanic Blacks in a Population-Based Case-Control Study
P23
Ren A1,2, Pi X1,2, Jin L1,2, Li Z1,2, Wang L1,2.
1Institute of Reproductive and Child Health, Peking University, Beijing,
China, 2Ministry of Health Key Laboratory of Reproductive Health, Peking
University, Beijing, China. Trace Elements in Placental Tissue and Risk of
Orofacial Clefts
P24
Brannen KC, Robinson BL, Mattson BA. Merck, West Point,
PA, United States. Detecting Teratogenicity with Micro-CT Skeletal
Evaluations in Nonclinical Studies
P25
Barbeau S, Adamo M, Pouliot L, Robinson K. Charles
River, Montréal, QC, Canada. An Assessment of Continuous Intravenous and
Subcutaneous Infusion Dosing in Embryo-Fetal Development Studies: Maternal and
Embryo-Fetal Parameters
P26
Solomon HM, Murzyn S, Rendemonti JE, Chapman SP, Junker BM,
Stanislaus DJ, Alsaid H. GlaxoSmithKline Pharmaceuticals, Collegeville, PA,
United States. Application of micro-CT Imaging in a Preliminary Embryo-Fetal
Development Study in New Zealand White Rabbits
P27
Schellpfeffer MA1, Strasburger JF2, Fihlo OB3, Bitant S4,
Wakai RT4. 1Medical College of Wisconsin, Milwaukee,
WI, United States, 2Children's Hospital of Wisconsin, Milwaukee, WI,
United States, 3Universidade de San Paulo, San Paulo, Brazil, 4University
of Wisconsin-Madison, Madison, WI, United States. Optically-Pumped
Magnetocardiography to Noninvasively Obtain Electrocardiograms in the
Developing Chick Embryo
P28
Emily M, McCuistion EA, Bailey M. Emporia State
University, Emporia, KS, United States. Changes in Cyp2b10 and Gsta4 Gene
Expression during Cyclophosphamide Exposure and Maternal Restraint Stress
P29
Conley JM, Lambright CS, Evans N, Medlock-Kakaley E, Wilson VS, Gray E. US EPA/ORD/NHEERL/TAD, Research Triangle Park, NC, United States. Adverse Effects of Gestational Exposure to Hexafluoropropylene Oxide Dimer Acid (GenX) in the Sprague-Dawley Rat
P30
Paradis F-H1, Beaudry
F1, Tavcar R1, Kubaszky R1, Downey AM1,
Ellemann-Laursen S2, Makin A2, Hill K3, Gilmore
R3, Singh P4, Hargitai J5, Spezia F4,
Forster R4, Authier S1. 1Citoxlab North
America, Montréal, QC, Canada, 2Citoxlab Denmark, Ejby, Denmark, 3Citoxlab
USA, LLC, Stilwell, KS, United States, 4Citoxlab France, Evreux, France,
5Citoxlab Hungary, Veszprem, Hungary. Interspecies Comparison of
Embryo-Fetal Data among Control Groups of Sprague-Dawley Rats, New Zealand
White Rabbits, and Gottingen Minipigs
P31
Williams AL1, Campetella S2, DeSesso JM1. 1Exponent,
Inc., Alexandria, VA, United States, 2Galderma, S.A., Lausanne, Switzerland.
Retinoid Teratogenicity: A Critical Evaluation of Contributing Properties
for Adapalene
P32
Buckley DM, Sidik A, Kar RD, Eberhart JK. The University
of Texas at Austin, Austin, TX, United States. Differentially Sensitive
Neurons in the Central Nervous System and Formation of Hindbrain Heterotopias
in Ethanol-Exposed Zebrafish
P33
Ding Z, Yang S, Pan L, McPherson
S. WuxiApptec, Suzhou, Wuzhong, China. Comparison of Historical
Control Data for Fertility and Early Embryonic Development Toxicity Parameters
in Sprague-Dawley Rats from Different Geographical Regions
P34
Katzman PJ. University
of Rochester Medical Center, Rochester, NY, United States. Pulmonary
Hypoplasia in a Lethal Case of Pallister-Hall Syndrome
P35
Hootnick DR1,2,3. 1Department of Orthopedic
Surgery, SUNY Upstate Medical University, Syracuse, NY, United States, 2Department
of Pediatrics, SUNY Upstate Medical University, Syracuse, NY, United States, 3Department
of Cellular and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY,
United States. Does Embryonic Arterial Maldevelopment Present a Risk Factor
for Congenital Long Bone Deficiencies?
P36
Hamm J1, Behl M2,
Ceger P1, Haendel M3, Marvel S4, Maull EA2,
Muriana A5, Reif D4, Tanguay RL6, Thessen A3,
Truong L6, Vallant M2, Walker N2, Ryan K2.
1ILS, Research Triangle Park, NC, United States, 2NIH/NIEHS/DNTP,
Research Triangle Park, NC, United States, 3Oregon State University,
Corvallis, OR, United States, 4North Carolina State University, Raleigh,
NC, United States, 5Biobide USA, Cambridge, MA, United States, 6Sinnhuber
Aquatic Research Laboratory, Oregon State University, Corvallis, OR, United States.
The National Toxicology Program’s Systematic Evaluation of the Application
of Zebrafish in Toxicology: SEAZIT
LB1
Zamek-Gliszczynski MJ1, Zhang X2,
Mudunuru J1, Du Y2, Chen JL2, Taskar KS3,
Huang J2, Huang Y2, Romach EH4. 1GlaxoSmithKline,
Collegeville, PA, United States, 2BioIVT, Santa Clara, CA, United
States, 3GlaxoSmithKline, Ware, United Kingdom, 4ViiV
Healthcare, Research Triangle Park, NC, United States. Effects of
Dolutegravir and Other Integrase Inhibitors on Folate Transport Pathways
LB2
Kancherla V1,2, Averbach H3,
Oakley Jr GP1,2. 1Department
of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA,
United States, 2Center for Spina Bifida Prevention, Department of
Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA,
United States, 3Department of Environmental Health, Emory University
Rollins School of Public Health, Atlanta, GA, United States. Nation-Wide Failure of Voluntary Folic Acid
Fortification of Corn Masa Flour and Tortillas with Folic Acid
LB3
Klos, KS; Goeden, HM; Fallace,
KL. Minnesota Department of Health, St. Paul, MN, United States. Combined
Boron Content in Infant Formula and Drinking Water Raises Developmental
Concerns
LB4
Wolf CJ1, Becker C2. 1Toxicity Assessment Division,
National Health and Environmental Effects Research Lab, US EPA, Research
Triangle Park, NC, United States, 2Oak Ridge Institute for Research
Education, Oak Ridge, TN. United States. Multicellular Organoid Model of
Human Palatal Fusion and Response to Valproic Acid
LB5
Hannas BR1, Coder PS2,
Harrison D2, Mikles K1, Papineni S3, Murphy L3,
Domoradzki J3, Rasoulpour RJ3, Terry C3. 1Corteva
Agriscience, Corteva Global Laboratory, Newark, DE, Untied States, 2Charles
River Laboratories, Ashland, OH, United States, 3Corteva
Agriscience, Indianapolis Headquarters, Indianapolis, IN, United States. Dietary
Route of Exposure for Rabbit Provides a Reliable, Relevant, and Conservative
Characterization of Developmental Toxicity
Chairpersons: Carl L. Keen, University of California–Davis and
Helen J. K. Sable, University of Memphis
Chairpersons: Christina D. Chambers, University of California–San Diego and
Marcy Stephens Powell, GlaxoSmithKline
P37
Schneuer FJ1, Milne E2,
Jamieson SE2, Pereira G3, Hansen M2, Barker A4,
Holland AJ5, Bower C2, Nassar N1.
1The Children's Hospital at Westmead Clinical School, The University
of Sydney, Sydney, NSW, Australia, 2Telethon Kids Institute, University
of Western Australia, Perth, WA, Australia, 3School of Public Health,
Curtin University, Perth, WA, Australia, 4Department of Paediatric Surgery,
Princess Margaret Hospital for Children, Perth, WA, Australia, 5The Children’s
Hospital at Westmead Clinical School, The University of Sydney, Sydney, NSW, Australia.
The Link between Male Genital Anomalies and Adult Male Reproductive
Disorders: A Population-Based Data Linkage Study Spanning over 40 Years
P38
Hrubec TC1,2, Vieira P1, McDonald
VA1. 1Edward Via College of Osteopathic Medicine Virginia
Campus, Blacksburg, VA, United States, 2VA-MD College of Veterinary Medicine,
Virginia Tech, Blacksburg, VA, United States. Hormones Anyone? How QACs
Reduce Reproductive Capability
P39
Howdeshell KL1, Shelby MD1, Blain RB2, Lunn RM1, Ross
P2, Taylor KW1, Witt KL1, Rooney AA1.
1NIEHS/NTP, Research Triangle Park, NC, United States, 2ICF,
Durham, NC, United States. NTP Monograph on the Systematic Review of
Occupational Exposure to Cancer Chemotherapy Agents and Adverse Health Outcomes
P40
Schanzer A1, Kappil M2, Blum J1, Chen L-C1, Chen
J2, Zelikoff J1. 1New York University, New
York, NY, United States, 2Mount Sinai Icahn School of Medicine, New York,
NY, United States. Differential Expression
Analysis of Preterm Birth Genes in Placenta of PM2.5 Exposed Mice Using RNAseq
P41
Bowman CJ1, Bono CP1, Nowland WS1, Ji C2.
1Pfizer, Groton, CT, United States, 2Pfizer, La Jolla, CA,
United States. Placental Transfer of the Immunoglobulin G Response to KLH in
Rats and Rabbits
P42
Nestoridi E1, Flaherty K2, Liberman RF1, Higgins CA1,
Yazdy MM1. 1Massachusetts Center for Birth Defects
Research and Prevention, Massachusetts Department of Public Health, Boston, MA,
United States, 2Katherine Flaherty Consulting, LLC, Franklin, MA, United
States. Implementation and Impact of Incorporating Prenatal Diagnoses of
Birth Defects into an Active State-Wide Surveillance System
P43
Howey XM1, Phelps D1, Weitekamp C1, Zurlinden TJ2,
Catron T1, Keely S3, Brinkman N3, Wheaton E3,
Tal T4. 1ORISE/US EPA/ORD/NHEERL/ISTD, Research Triangle
Park, NC, United States, 2US EPA/ORD/NCCT, Research Triangle Park, NC,
United States, 3US EPA/ORD/NERL/SED, Research Triangle Park, NC, United
States, 4US EPA/ORD/NHEERL/ISTD, Research Triangle Park, NC, United States.
Identifying Microbial Markers of Xenobiotic Exposures in Zebrafish
P44
Watanabe M1,2, Ford SM1,2, Liu Y3, Broberg MC4, Kim
JW1, Herring AI1, Rollins AM3, Zhu A5,
Kumar N5, Lapierre-Landry M3, Kolesova H1,2, Jenkins
MW3. 1Case Western Reserve University School of Medicine,
Cleveland, OH, United States, 2Department of Pediatrics, Rainbow Babies
and Children's Hospital, Cleveland, OH, United States, 3Department of
Biomedical Engineering, Case Western Reserve University, School of Engineering,
Cleveland, OH, United States, 4Department of Pediatrics, Rainbow Babies
and Children's Hospital, Cleveland, OH, United States, 5Hathaway Brown,
Science Research & Engineering Program, Shaker Heights, OH, United States. Novel
Methods for Imaging Congenital Heart Defects in an Avian Model of Fetal Alcohol
Spectrum Disorder
P45
Zhao J-P1, Sheehy O1, Berard A1,2. 1CHU
Sainte Justine, Montréal, QC, Canada, 2Faculty of Pharmacy, University
of Montréal, Montréal, QC, Canada. Impact of Nonadjustment for Smoking
Status during Pregnancy and Prepregnancy Obesity on the Association between
Gestational Antidepressant Use and Risk of Low Birth Weight Infants
P46
Jo YS. Department of Obstetrics and Gynecology, College of Medicine, St.
Vincent's Hospital, The Catholic University of Korea, Suwon, Kyeonggi, The Republic
of Korea. Nonobstetric Surgery during Pregnancy and Perioperative
Fetal Monitoring
P47
Palmer JA1, Glatt CM2, Colwell MR1, Donley EL1,
Burrier RE1. 1Stemina Biomarker Discovery, Inc., Madison,
WI, United States, 2The Chemours Company, Wilmington, DE, United States.
Developmental Toxicity Testing of Gaseous Chemicals with a Human Pluripotent
Stem Cell-Based Assay
P48
DeSesso JM1,2, Coder PS3, York RG4, Budinsky RA5,
Pottenger LH6, Sen S7, Lucarell JM3, Bevan CJ8,
Bus JS9. 1Exponent, Alexandria, VA, United States,
2Georgetown University School of Medicine, Washington, DC, United States,
3Charles River Laboratories, Ashland, OH, United States, 4RG
York and Associates LLC, Cincinnati, OH, United States, 5Dow Chemical
Company, Midland, MI, United States, 6LHP Tox Consult LLC, Midland, MI,
United States, 7Chrlaes River Laboratories, Ashland, OH, United States,
8HSIA, Arlington, VA, United States, 9Exponent, Midland, MI,
United States. Trichloroethylene (TCE) in Drinking Water Does Not Cause
Heart Defects in Rats
P49
Baker AE1, Fuchs A2, Millen L1, Ervin T1, Luetjens
M2, Weinbauer GF2. 1Covance Laboratories
Inc., Madison, WI, United States, 2Covance Preclinical Services GmbH,
Muenster, Westphalia, Germany. Intranasal Oxytocin Administration as a
Procedure for Handling Infant Rejections in Long‑Tailed Macaques (Macaca fascicularis)
P50
Pitsava G1, Feldkamp ML2,
Pankratz N3,
Lane J3, Kay DM4, Shaw GM5, Reefhuis J6,
Jenkins MM6,
Almli LM6,7,
Werler M8, Olshan AF9, Pangilinan F10, Brody LC10, Romitti PA11, Mills
JL1, UW Center for Mendelian
Genomics12, NISC Comparative Sequencing Program13, The National
Birth Defects Prevention Study14. 1NICHD, NIH, Bethesda, MD, United States,
2University of Utah, Salt Lake City, UT, United States, 3University
of Minnesota, Minneapolis, MN, United States, 4New York Department of
Health, Albany, NY, United States, 5Stanford University, Stanford, CA,
United States, 6NCBDDD, CDC, Atlanta, GA, United States, 7Carter
Consulting Inc., Atlanta, GA, United States, 8Boston University, Boston,
MA, United States, 9University of North Carolina, Chapel Hill, NC, United
States, 10NHGRI, NIH, Bethesda, MD, United States, 11Univeristy
of Iowa, Iowa City, IA, United States, 12University of Washington, Seattle, WA, United States, 13National Institutes of Health, Rockville, MD, United States, 14Centers for Disease
Control and Prevention, Atlanta, GA
United States. Exome Sequencing Identifies Genes Involved in Cell
Adhesion and Migration in Bladder Exstrophy Cases
P51
Kancherla V1, Ma C2, Grant G3, Lee HC2, Hintz SR2,
Carmichael SL2. 1Department of Epidemiology, Rollins
School of Public Health, Emory University, Atlanta, GA, United States, 2Department
of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University
School of Medicine, Stanford, CA, United States, 3Department of Neurosurgery,
Stanford University School of Medicine, Stanford, CA, United States. Factors
Associated with First-Year Mortality in Infants with Myelomeningocele
P52
Santiago-Colón A1, Rocheleau C1, Chen I-C1, Sanderson W2,
Waters M1, Lawson CC1, Langlois PH3, Cragan J4,
Reefhuis J4. 1Centers for Disease Control and Prevention,
National Institute for Occupational Safety and Health, Cincinnati, OH, United States,
2University of Kentucky, Lexington, KY, United States, 3Texas
Department of State Health Services, Birth Defects Epidemiology and Surveillance
Branch, Austin, TX, United States, 4National Center on Birth Defects
and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta,
GA, United States. Association between Maternal Occupational Exposure to
Polycyclic Aromatic Hydrocarbons and Rare Birth Defects of the Face and Central
Nervous System in the National Births Defects Prevention Study
P53
Gorgui J1,2, Sheehy O2, Trasler J3, Fraser W4,
Berard A1,2. 1Faculty of Pharmacy, University of Montréal,
Montréal, QC, Canada, 2Research Center-CHU Sainte-Justine, Montréal, QC, Canada, 3Department
of Pediatrics, Human Genetics and Pharmacology & Therapeutics, McGill University,
Montréal, QC, Canada, 4Faculty of Medicine and Health Sciences, University
of Sherbrooke, Sherbrooke, QC, Canada. Medically Assisted Reproduction and
the Risk of Being Born Small for Gestational Age
P54
Papadopoulos EA, Fisher S, Howley MM, Browne ML. New York
State Department of Health, Albany, NY, United States. Maternal Hereditary
Hemolytic Anemia and Birth Defects in the National Birth Defects Prevention
Study
P55
Krause KH1,2, Ailes E1,
Gilboa SM1, Tong V1, Cragan J1, Delaney A1,
Jones A1, Nahabedian J1, Olson SM1,3, Roth
N1, Smoots A1, Yowe-Conley T1, Meaney-Delman D1,
Honein M1. 1Centers for Disease Control
and Prevention, Atlanta, GA, United States, 2Epidemic Intelligence Service,
Atlanta, GA, United States, 3G2S Corporation, San Antonio, TX, United
States. An Evaluation of Zika Birth Defects Surveillance: A Model for Rapid
Surveillance of Birth Defects during an Emergency Response—United States,
2018
P56
Michikawa T1,2, Yamazaki S2, Ono M2, Kuroda T3, Nakayama
SF2, Suda E2, Isobe T2, Iwai-Shimada M2,
Kobayashi Y2, Tamura K2, Yonemoto J2, Kawamoto
T2, Nitta H2. 1Toho University, Tokyo, Japan
2National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
3Keio University School of Medicine, Tokyo, Japan. Fish Intake Was
Inversely Associated with Congenital Gastrointestinal Tract Atresia: The Japan Environment
and Children’s Study
P57
Lemelin M1,2, Boukhris T1,2, Sheehy O2, Berard A1,2.
1Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada, 2CHU
Sainte-Justine Research Center, Montréal, QC, Canada. Prevalence and
Predictors of ADHD Medication Use in a Cohort of Pregnant Women
P58
McCall JL, Varney ME, Blethen KE, Elliott M, Damron FH,
Barnett JB. West Virginia University, Morgantown, WV, United States. Prenatal
Exposure to Cadmium Alters the Transcriptome of Regulatory T-cells in C57BL/6
Mice
P59
Harrison DB, Herberth MT,
Edwards TL, Hackman ML, Coder PS. Charles River Laboratories, Ashland, OH,
United States. Evaluation of Pregnancy Rates and Developmental Toxicity
Endpoints in Time-Mated Mice
P60
Shankar P1, Geier M1, Truong L1, McClure R2, Pande
P2, Waters KM2, Tanguay RL1. 1Department
of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR,
United States, 2Pacific Northwest National Laboratory, Richland, WA,
United States. Coupling Transcriptomics and Developmental Toxicity in
Zebrafish to Classify Polycyclic Aromatic Hydrocarbons (PAHs)
P61
Adamo M, Jouniaux J, Barbeau S, Pouliot L, Robinson K.
Charles River Montréal, Montréal, QC, Canada. A Microsampling Method for
Juvenile Mouse Studies
P62
Cope H, Blake BE, Fenton SE. NTP Laboratory, Division
of the NTP, NIEHS, Durham, NC, United States. Evaluation of Puberty and
Metabolic Disease in CD-1 Mice Exposed to PFOA or GenX
P63
Murphy CJ1, Goodnight SY1, Babineau RZ1, Dorato MA1,
Harris SB2. 1Smithers Avanza, Gaithersburg, MD, United
States, 2Stephen B. Harris Group, San Diego, CA, United States. Evaluation
of the Teratogenic Effects Produced When Dimethadione Was Administered to
Pregnant Sprague Dawley Rats for Technical Training Program
P64
McCuistion EA, Bailey M, Emily M. Emporia State University,
Emporia, KS, United States. Hemp Oil Does Not Have Adverse Effects on Fetal
Development in ICR Mice
P65
Quevedo C1, De Croze N2,
Alday A1, Muriana A1, Léonard M2.
1Biobide, San Sebastian, Gipuzkoa, Spain, 2L’Oreal, Research
& Innovation, Aulnay-sous-Bois, France. Zebrafish and Medaka as
Alternative Models for Developmental Toxicity Assessment of Chemicals
(Including Behavior As an End Point)
P66
Ttayem YR, Veeramuthu S, Rashid AN,
Reginald SP, Fadel RA. Arabian Gulf University, Manama, Bahrain. Effects
of Melamine Administration during Pregnancy on Fetal Bone Ossification
P67
Wong L, Fullerton A, Halpern W. Genentech, Inc., South San Francisco, CA, United States. Predicting Embryofetal Developmental Toxicity from In Vitro Assays
P68
Ceger P1, Bell S1, Choksi N1, Hamm J1, Daniel
A1, Allen DG1, Kleinstreuer NC2. 1ILS,
Research Triangle Park, NC, United States, 2NIH/NIEHS/DNTP/NICEATM, Research
Triangle Park, NC, United States. Application of a Controlled Vocabulary to
Curated Databases of In Vivo
Developmental Toxicity Data
P69
Hootnick DR1,2,3. 1Department of Orthopedic
Surgery, SUNY Upstate Medical University, Syracuse, NY, United States, 2Department
of Pediatrics, SUNY Upstate Medical University, Syracuse, NY, United States, 3Department
of Cellular and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY,
United States. Dystrophic Fibula: New Terminology for Absent Fibula
P70
Mohamed LM1, Guled IA1,
Hassan FA1, Hassan AO1, Faqi AS2.
1Benadir Hospital, Mogadishu, Benadir, Somalia, 2ASF Scientific
Solutions, Portage, MI, United States. Cases of Congenital Heart Defects in
Benadir Hospital, Mogadishu (Somalia)
LB6
Hayatullah G, Han L, Yidan Y. Third Gynecology Department of First Affiliated
Hospital of Zhengzhou University, Zhengzhou, Henan, China. Clinical and
Pathological Analysis of 21 Cases of Malignant Transformation of Endometriosis
LB7
Elizondo-Plazas A,
Ibarra-Ramírez m, Calzada-Dávila m, Jasso-Gaona RS, Salazar-Rivera R, Martínez-de-Villarreal LE. University Hospital "Dr. José E.
Gonzalez," Universidad Autonoma de nuevo Leon, Monterrey, Nuevo León,
Mexico. Increased Frequency of Flow Regression syndrome in a
Population of Northeast Mexico
LB8
Yao H1, Wu W1, Zhao HW1, Wang J1,
Negraes PD1,3, Muotri A1,3,4, HaddadG1,2,4. 1Department of Pediatrics, University
of California–San Diego, La Jolla, CA, United States, 2Department
of Neuroscience, University of California–San Diego, La Jolla, CA, United
States, 3Department of Cellular and Molecular Medicine, Stem Cell
Program, University of California–San Diego, La Jolla, CA, United States,
4The Rady Children’s Hospital, San Diego, CA, United States. Methadone Attenuates Neural Network Activity in Human
Cortical Organoids
LB9
Trujillo CA, Jones KL, Del Campo M, Muotri AR. University of California–San
Diego, School of Medicine, Department of Pediatrics, Rady Children's Hospital
San Diego, La Jolla, CA, United States. A Human Neurodevelopmental Model of
Fetal Alcohol Spectrum Disorders
LB10
Laffan SB1, Kohrs L1, Kambara T3, Rambo M1, Roulois A2, Turner S1. 1GlaxoSmithKline, In Vitro In Vivo Translation, Collegeville, PA, United States, 2GlaxoSmithKline, In Vitro In Vivo Translation, Ware, United Kingdom. 3AbbVie, Preclinical Safety, North Chicago, IL, United States. Brain Weight Effect of Ambrisentan in Juvenile Rat Toxicity Study Associated with Breathing Sounds, Apnea, and Sustained Hypoxemia
Chairpersons: Nicole Churchill Kleinstreuer, NTP Interagency Center
for the Evaluation of Alternative Toxicological Methods, NIEHS and
Jessica A. Palmer, Stemina Biomarker Discovery, Inc.
Chairpersons: Nelson Pace, Exponent, Inc. and
Sonja A. Rasmussen, University of Florida
Chairpersons: Elise Madison Lewis, Charles River Laboratories and Ida M. Washington, West Virginia University
Chairpersons: Suzan L. Carmichael, Stanford University and
Mary Alice Smith, University of Georgia
Chairpersons: Deborah Covington, Pharmaceutical Product Development, Inc. and
Lewis B. Holmes, MassGeneral Hospital for Children
Chairpersons: Pragati Sawhney Coder, Charles River and
Susan L. Makris, National Center for Environmental Assessment, US EPA
Chairpersons: Tamara L. Tal, US Environmental Protection Agency and
David C. Volz, University of California–Riverside