Program

Meeting Agenda

Society for Birth Defects Research and Prevention 2021 Annual Meeting—Building Bridges in Birth Defects Research and Prevention: From Innovation to Application

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Please note that all times listed are in EDT – Eastern Daylight Time (US).

Only sessions designated with CME are eligible for Continuing Medical Education credit.

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Thursday, June 24, 2021
11:00 AM–11:10 AM
President's Welcome
BDRP President, Elise Madison Lewis, Charles River Laboratories


11:10 AM–11:45 AM
CME
Josef Warkany Lecture (L1)
Reactive Oxygen Species and DNA Damage/Repair in Developmental Disorders
Chairperson: Elise Madison Lewis, Charles River Laboratories
Lecturer: Peter Wells, University of Toronto


11:45 AM–12:30 PM
CME
Robert L. Brent Lecture—Teratogen Update (L2)
Identifying New Human Teratogens: Revisiting Shepard's Criteria
Chairperson: Elise Madison Lewis, Charles River Laboratories
Lecturer: Sonja A. Rasmussen, University of Florida College of Medicine


12:30 PM–1:00 PM
Break


1:00 PM–3:30 PM
Graduate Student and Postdoctoral Fellow Platform Session 1
Organized by the Student Affairs Committee
Chairpersons: Paul B. Bushdid, Covance Laboratories Inc. and
Laura Carlson, US Environmental Protection Agency
Full Schedule


Presenting author is underlined.


1:00 PM–1:05 PM
Introduction


1:06 PM–1:24 PM
1
Enhanced Ethanol-initiated, Reactive Oxygen Species-dependent Embryopathies in Breast Cancer 1 (Brca1) Knockout Mouse Embryos in Culture
Afsharian K , Wells PG. University of Toronto, Toronto, ON, Canada


1:24 PM–1:42 PM
2
COVID-19 and Its Effects on the Newborn: A Rapid Review of Available Data
Valladares DA, Kramer EF, Powell MM, Pomputius A, Rasmussen SA. University of Florida, Gainesville, FL, United States


1:42 PM–2:00 PM
3
The Effects of Bisphenols on Endochondral Ossification in Murine Limb Bud Cultures
Iskandarani L1, Hales BF2, Robaire B2. 1Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada


2:00 PM–2:18 PM
4
A Novel Molecular Basis for Breast Cancer 1 Protein (BRCA1) Protection of the Fetal Brain from Developmental Disorders Mediated by Reactive Oxygen Species
Drake DM, Wells PG. University of Toronto, Toronto, ON, Canada


2:18 PM–2:36 PM
5
Evaluation of Viral Entry and Cellular Passage of Zika Virus Immune Complexes in a Tissue Culture Model of the Maternal-Fetal Interface
Momben Abolfath S, Xu Y, He Y, Eller N, Norton M, Struble E. US Food and Drug Administraition, Silver Spring, MD, United States


2:36 PM–2:54 PM
6
Exploring Airshed and Watershed Exposure Pathways as Mediators of the Association between Proximity to Surface Mining and Adverse Birth Outcomes in Central Appalachia
Ruktanonchai CW1, McKnight M2, Marr L1, Krometis L-A1, Buttling L2, Ranganathan S1, Kolivras K1, Gohlke J1. 1Virginia Tech, Blacksburg, VA, United States, 2Mitre, McLean, VA, United States


2:54 PM–3:12 PM
7
Sex and Strain-Dependent Effects of Prenatal Alcohol Exposure on Craniofacial and Brain Development in Mice
Boschen KE, Fish EW, Cannizzo MD, Dragicevich CJ, Peterson RL, Steensen MC, Parnell SE. University of North Carolina, Chapel Hill, NC, United States


3:12 PM–3:30 PM
8
Standardization and Validation of a Scalable Human Neural Rosette Microarray Assay for Assessment of Neural Tube Defect Risk and Developmental Neurotoxicity
Knight GT, Fedorchak N, Lundin B, Ashton RS. University of Wisconsin, Madison, WI, United States


3:30 PM–4:00 PM
Break


4:00 PM–5:00 PM
President’s Welcome Social


Friday, June 25, 2021
11:00 AM–11:30 AM
F. Clarke Fraser New Investigator Award (L3)
Consequentialist Epidemiology of Birth Defects: Early Career Experiences and Key Findings from National and Global Research
Chairperson: Philip Lupo, Baylor College of Medicine
Lecturer: Vijaya Kancherla, Emory University


11:30 AM–12:00 Noon
James G. Wilson Publication Award
Exploratory analysis of machine learning approaches for surveillance of Zika‐associated birth defects
Chairperson: Russell S. Kirby, USF College of Public Health
Lecturers: Richard Lusk, Deloitte Consulting, LLP; John Zimmerman, Deloitte Consulting, LLP and Nicole M. Roth, Centers for Disease Control and Prevention


12:00 Noon–12:30 PM
Patricia Rodier Mid-Career Award for Research and Mentoring (L4)
Manganese Overexposure during Development: Environmental and Genetic Effects
(Joint with DNTS)
Chairpersons: Philip Lupo, Baylor College of Medicine and Sonia Minnes, Case Western Reserve University
Lecturer: Michael T. Williams, Cincinnati Children’s Research Foundation


12:30 PM–1:00 PM
Agnish Fellowship Lecture(L5)
Education, Service, and Career Paths in the Multidisciplinary Science of Birth Defects Causation and Prevention
Chairperson, Christina M. Carruthers, Janssen Pharmaceuticals
Lecturer: Ronald Hood, The University of Alabama


1:00 PM–1:30 PM
Break


1:30 PM–3:00 PM
Multidisciplinary Research Needs Workshop
Chairpersons: Dana L. Shuey, Incyte and
William Slikker, Jr., National Center for Toxicological Research, US FDA
Full Schedule


1:30 PM–2:00 PM
Overview of Workshop Goals and Progress
Dana L. Shuey, Incyte

Research Priorities and Funding Opportunities
Daniel Mellon, Center for Drug Evaluation and Research, US FDA and Suzanne E. Fenton, National Institute of Environmental Health Sciences


2:00 PM–2:30 PM
Concurrent Breakout Sessions
Topic 1: Promises and Challenges of Human Induced Pluripotent Stem Cells (hiPSC), Organoids and Engineered 3D Models in Birth Defect Research
Discussion Lead: Thomas B. Knudsen, US Environmental Protection Agency
Scribe: William Slikker Jr., National Center for Toxicological Research, US FDA

 Topic 2: Prenatal Diagnostics and Risk Factors for Preterm Birth, Low Birth Weight, Malformations, Maternal Mortality; Cultural, Ethnic, and Socioeconomic Factors
Discussion Lead: Christina D. Chambers, University of California San Diego
Scribe: Laura Dishaw, US Environmental Protection Agency

 Topic 3: Single Cell -Omics Meta-Data/resources Available on Various Platforms for the Birth Defect Research Community: How to Utilize These Datasets
Discussion Lead: Madhumita Basu, Nationwide Children's Hospital
Scribe: Alan M. Hoberman, Charles River


2:30 PM–3:00 PM
Reassemble to Discuss Progress from Breakout Sessions
William Slikker Jr., National Center for Toxicological Research, US FDA


1:30 PM–3:00 PM
Professional Development Workshop
Organized by the Membership Committee and Student Affairs Committee
Chairpersons: Paul B. Bushdid, Covance Laboratories Inc. and
Deirdre K. Tucker, Charles River Laboratories

Full Schedule


1:30 PM–1:35 PM
Introduction
Paul B. Bushdid, Covance Laboratories Inc.


1:35 PM–1:55 PM
Career Options for Trainees
Tacey E.K. White, Aclairo Pharmaceutical Development Group, Inc.


1:55 PM–2:15 PM
Changing Professional Paths Mid-Career
Christine Perdan Curran, Northern Kentucky University


2:15 PM–2:35 PM
Balancing Career and Family
Terry C. Hrubec, E. Via Virginia College of Osteopathic Medicine


2:35 PM–2:55 PM
Career Challenges
Ida M. Washington, West Virginia University


2:55 PM–3:00 PM
Closing Remarks


Monday, June 28, 2021
11:00 AM–11:45 AM
Keynote Lecture
Pregnancy and the Perils of Precaution: Toward a New Paradigm for the Ethics of Including Pregnant People in Vaccine Research and Deployment (L6)
(Joint with OTIS)
Chairperson: Susan L. Makris, US Environmental Protection Agency
Speaker: Carleigh Krubiner, Center for Global Development and Johns Hopkins Berman Institute of Bioethics


11:45 AM–12:30 PM
BDRP and ETS Exchange Lecture
Covid-19 in Pregnancy and Lactation: US and European Perspectives on Research and Public Health
(Joint with OTIS)
Chairpersons: Susan Makris, US Environmental Protection Agency and
Manon Beekhuijzen, Charles River

BDRP
Christina D. Chambers, University of California San Diego

ETS
David Baud, Centre Hospitalier Universitaire Vaudois (CHUV)


12:30 PM–1:00 PM
Break


1:00 PM–3:00 PM
Wiley Symposium
Approaches for Mechanistic Evidence Analysis in Hazard Evaluation of Reproductive Toxicology Data
Chairpersons: Xabier Arzuaga, US Environmental Protection Agency
and Erin Yost, US Environmental Protection Agency
Full Schedule


1:00 PM–1:05 PM
Introduction
Xabier Arzuaga, US Environmental Protection Agency


1:05 PM–1:25 PM
S1
The Hazards of Endocrine Disrupting Chemicals Partially Overlap with the Hazards of Reproductive Toxicants
Michele La Merrill, University of California, Davis


1:25 PM–1:45 PM
S2
A New Approach Methods-Based Integrated Assessment of Estrogenicity of Alkylphenols
Fabian Grimm, ExxonMobil Biomedical Sciences, Inc.


1:45 PM–2:05 PM
S3
Application of Key Characteristics in Support of Identifying Chemicals with Reproductive Hazard Traits
Lauren Zeise and Francisco Moran, California Environmental Protection Agency


2:05 PM–2:25 PM
S4
Application of the Key Characteristics Approach to Female Reproductive Hazard Identification: Benzo[a]pyrene as a Case Example
Ulrike Luderer, University of California, Irvine


2:25 PM–2:45 PM
S5
Applying the Key Characteristics Approach to Evaluate Mechanistic Evidence for Qualitative and Quantitative Weight of Evidence to Support Risk Assessment: A Case Study with Benzo[a]Pyrene-Induced Male Reproductive Toxicity
Ingrid Druwe US Environmental Protection Agency


2:45 PM–3:00 PM
Discussion


1:00 PM–3:00 PM
The Effects of Water Fluoridation on Neurodevelopment and Other Health Outcomes Symposium
(Joint with DNTS)
Chairpersons: Kembra L. Howdeshell, National Institute of Environmental Health Sciences and Kyla Taylor, National Institute of Environmental Health Sciences
Full Schedule


1:00 PM–1:05 PM
Introduction
Kembra L. Howdeshell, National Institute of Environmental Health Sciences


1:05 PM–1:30 PM
S6
Fluoride Intake and Exposure and Oral Health Effects
E. Angeles Martinez Mier, Indiana University School of Dentistry


1:30 PM–1:55 PM
S7
Early-Life Exposures to Fluoride and Child Neurodevelopmental Outcomes
Christine Till, York University


1:55 PM–2:20 PM
S8
Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects
Kyla Taylor, National Institute of Environmental Health Sciences


2:20 PM–2:45 PM
S9
Fluoride Exposure and Neuroendocrine Outcomes among Youth in the United States
Ashley Malin, Keck School of Medicine, University of Southern California


2:45 PM–3:00 PM
Discussion


1:00 PM–3:00 PM
Neglected Diseases/Neglected Patients Symposium
Chairpersons: Jane Stewart, Apconix, Melissa S. Tassinari, Consultant, and Belen Tornesi, Medicines for Malaria Venture
Full Schedule


1:00 PM–1:05 PM
Introduction
Melissa S. Tassinari, Consultant


1:05 PM–1:30 PM
S10
Global Efforts for Eradication of Malaria: A Focus on Pregnant and Lactating Women
Belen Tornesi, Medicines for Malaria Venture


1:30 PM–1:55 PM
S11
The Use of a Humanized Mouse Model to Assess Antimalarial Efficacy and Identify Optimal Drugs Combinations
Claudia Demarta-Gatsi, Medicines for Malaria Venture


1:55 PM–2:20 PM
S12
Working in Operationally Challenging Situations: How Do We Get Malarial Drugs to Pregnant and Lactating Women in the Real World?
Bhargavi Rao, Médecins Sans Frontières (MSF) UK


2:20 PM–2:45 PM
S13
Above All Do No Harm: How Can Pregnancy Outcomes for Malarial Patients Be Monitored and How Can Benefit-Risk Be Assessed?
Stephanie Dellicour, Liverpool School of Tropical Medicine


2:45 PM–3:00 PM
Discussion


3:00 PM–3:30 PM
Break


3:30 PM–4:30 PM
Poster Session 1
Attended for Questions & Answers
Posters P1–P17 and LB1–LB3
Poster Listings


 
Presenting author is underlined.

P1           Abstract Withdrawn

P2           Congenital Infections in Twin Pregnancies: A Narrative Review
Daza M1, Valencia D2, Mulkey SB3, Mercado MM4, Moore CA2. 1Vysnova Partners, Bogotá, Colombia, 2Centers for Disease Control and Prevention, Atlanta, GA, United States, 3Children's National Hospital, Washington, DC, United States, 4Instituto Nacional de Salud, Bogotá, Colombia

P3           Gestational Fluoride Exposure and Birth Outcomes: The MIREC Cohort
Goodman CV1, Hall MK1, Green R1, Hornung R2, Martinez-Mier EA3, Lanphear B4, Till C5. 1Faculty of Health, York University, Toronto, ON, Canada, 2Retired, Loveland, OH, United States, 3Indiana University School of Dentistry, Indianapolis, IN, United States, 4Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, 5York University, Toronto, Toronto, ON, Canada

P4           Validation Studies to Assess Toxicological Endpoints of Group Housed Pregnant Rabbits for Use in Reproductive Toxicology Studies
Sheikh I, Clubb SK, Mooney K. Charles River Laboratories, Edinburgh, United Kingdom

P5           Implementation of the Key Characteristics of Male Reproductive Toxicants to Synthesize Mechanistic Eevidence: A Case Study of Benzo[a]pyrene
Blake BE1, Arzuaga X2, Druwe I1. 1US EPA, Research Triangle Park, NC, United States, 2US EPA, Washington, DC, United States

P6           Epidemiology of Nonsyndromic, Orofacial Clefts in Texas: Differences by Cleft Type and Presence of Additional Defects
Navarro Sanchez ML1, Agopian AJ1, Swartz MD2, Canfield MA3, Langlois PH3. 1Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 2Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, United States, 3Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States

P7           Validation of Zebrafish Embryotoxicity Test (ZET) As a Qualified Alternative Assay For Its Regulatory Use
Alday A, Solis JC, Muriana A, Quevedo C. BBD BioPhenix-BIOBIDE, Donostia, Spain

P8           Comparing Socio-Demographic Characteristics of Mothers Who Did and Did Not Participate in a Survey Related to the Prevention of Neural Tube Defects
Betancourt D1, Shumate CJ1, Canfield MA2, Ethen MK1, Navarro Sanchez ML3.1Texas Department of State Health Services, Austin, TX, United States, 2Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 3Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States

P9           Early Neonatal Mortality among Babies Born with Spina Bifida in Finland, 2000–2014
Kancherla V1, Mowla S1, Räisänen S2, Gissler M3. 1Emory University, Atlanta, GA, United States, 2Tampere University of Applied Sciences, Highland Heights, KY, United States, 3THL Finnish Institute of Health and Welfare, Helsinki, Finland

P10         Moderate Prenatal Alcohol Exposure Increases Toll-Like Receptors Activity Detectable in Umbilical Cord Blood at Birth
Maxwell JR1, Noor S1, Pavlik N1, Rodriguez D2, Enriquez Marquez L2, DiDomenico J1, Bakhireva L2. 1University of New Mexico, Albuquerque, NM, United States, 2University of New Mexico, College of Pharmacy, Albuquerque, NM, United States

P11         Epidemiology of Coloboma: Prevalence and Patterns in Texas, 1999–2014
Chambers T1, Keyzer M1, Benjamin RH2, Shumate CJ3, Le M3, Canfield MA4, Lewis RA1, Hufnagel RB5. Agopian 002, Brooks BP5, Mitchell LE6, Lupo PJ7. 1Baylor College of Medicine, Houston, TX, United States, 2Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 3Texas Department of State Health Services, Austin, TX, United States, 4Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 5National Eye Institute, Bethesda, MD, United States, 6University of Texas School of Public Health, Houston, TX, Unites States, 7Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, Unites States

P12         Identifying Congener-Specific Half-Lives of Polychlorinated Biphenyls: A Mapping Review of the Literature
S EPA, Morrisville, NC, United States, 2US EPA, Durham, NC, United States, 3ICF International, Durham, NC, United States

P13         Racial and Ethnic Disparities in Infant Mortality among Infants with Birth Defects in North Carolina, 2003–2017
Forestieri NE1, Lee RC2, Avery M2. 1NC Birth Defects Monitoring Program, Raleigh, NC, United States, 2NC State Center for Health Statistics, Raleigh, NC, United States

P14         Infant Exposure to Chemicals via Human Milk: Next 22 High Priority Chemicals Under Review at US EPA
Cooper C. ORISE Fellow, Alexandria, VA, United States

P15         Assessing Adult Motor Function in Three Genotypes of Mice Exposed to Benzo[a]Pyrene During Early Brain Development
Perry C, Foster E, Niang D, Clough K, Forrest T, Curran CP. Northern Kentucky University, Highland Heights, KY, United States

P16         Extent and Effects of Quaternary Ammonium Disinfectant Exposure in People
Hrubec TC1, Seguin RP2, Xu L3, Cortopassi GA4, Datta S4, Hanlon AL5, Lozano AJ5, McDonald VA6, Healy 006, Anderson TC6, Musse NM6, Williams RT6. 1E. Via College of Osteopathic Medicine, Blacksburg, VA, United States, 2Department of Medicinal Chemistry, School of Pharmacy, Seattle, WA, United States, 3Department of Medicinal Chemistry, School of Pharmacy, Albuquerque, NM, United States, 4Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA, United States, 5Center for Biostatistics and Health Data Science, Roanoke, VA, United States, 6E. Via College of Osteopathic Medicine–Virginia, Blacksburg, VA, United States

P17         Exposure to Camel Snus In Utero Causes Skeletal Defects
Vera-Colon MKM, Soh R, Sparks NRL, Walker LM, zur Nieden NI. University of California, Riverside, Riverside, CA, United States

LB1         Current Breast Milk PFAS Levels in the US and Canada: After All This Time Why Don't We Know More?
Fenton SE1, Verner M-A2, Goeden H3, Naiman DQ4, Marchitti SA5, Hines EP6, Lehmann GM7, LaKind JS8. 1DNTP/NIEHS/NIH, Research Triangle Park, NC, United States; 2Université de Montréal, Montréal, QB, Canada; 3Minnesota Department of Health, Environmental Health Division, St. Paul, MN, United States; 4The Johns Hopkins University, Baltimore, MD, United States; 5LaKind Associates, LLC, Commerce City, CO, United States; 6US Environmental Protection Agency, Research Triangle Park, NC, United States; 7Center for Public Health and Environmental Assessment, Office of Research & Development, Research Triangle Park, NC, United States; 8LaKind Associates, LLC; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Catonsville, MD, United States

LB2         Incidence of Neurologic Findings in Esophageal Atresia Cohort at a Single Institution: A Retrospective Analysis
Evanovich DM1, Wang JT2, Jennings RW3, Bajic D4. 1Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital and Tufts University School of Medicine, Boston, MA, United States, 2Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States, 3Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, Unites States, 4Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States

LB3         Brain Organoids to Study SARS-Cov-2 Infection of Developing CNS
Smirnova L, Bullen CK, Hogberg HT, Pekosz A, Bishai W, Hartung T. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States

 
7:00 PM–9:00 PM
BDRP Trivia Night Social
Organized by the Student Affairs Committee
(Space is limited for this event)


Tuesday, June 29, 2021
10:00 AM–10:45 AM
New and Prospective Member Meet and Greet
Organized by the Membership Committee


11:00 AM–12:30 PM
Platform Session 2
Chairpersons: Maia M. Green, ExxonMobil Biomedical Sciences, Inc. and
Kristal A. Rychlick, Johns Hopkins University Bloomberg School of Public Health
Full Schedule


Presenting author is underlined.


11:00 AM–1:05 PM
9
Tracking Development in the First Two Years of Life Among Children with Possible Congenital Zika Virus Exposure: 50 US States and the District of Columbia
Neelam V1, Woodworth K1, Chang DJ1, Roth NM1, Reynolds MR1, Tong VT1, Anderson K1, Mulkey SB2, DeBiasi OO2, Biddle C2, Lee EH3, Lash MK3, Godred-Cato S1, Gilboa SM1, Honein MA1, Moore CA1. 1Centers for Disease Control, Atlanta, GA, United States, 2Children's National Hospital, Washington, DC, United States, 3New York City Department of Health and Mental Hygiene, Long Island Ciety, NY, United States


11:15 AM–11:30 AM
10
Risk of Birth Defects by Pregestational Type 1 or Type 2 Diabetes: National Birth Defects Prevention Study, 1997–2011
Marchincin SL1, Howley MM2, Van Zutphen AR2, Fisher SC2, Nestoridi E3, Tinker S4, Browne ML2. 1New York State Department of Health, Buffalo, NY, United States, 2New York State Department of Heath, Albany, NY, United States, 3Massachusetts Center for Birth Defects Research and Prevent, Department of Public Health, Boston, MA, United States, 4National Center on Birth Defects and Developmental Disabilities; CDC, Atlanta, GA, United States


11:30 AM–11:45 AM
11
Co-Occurring Birth Defects in Children with Nonsyndromic Microtia
Schraw JM1, Benjamin RH2, Scott DA3, McLean SD4, Northrup H5, Langlois PH6, Canfield MA6, Scheuerle AE7, Schaaf OO1, Ray, JW8, Chen H9, Swartz MD10, Agopian AJ11, Lupo PJ12. 1Baylor College of Medicine, Houston, TX, United States, 2Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, Houston, TX, United States, 4Baylor College of Medicine, San Antonio, TX, United States, 5University of Texas Health Science Center at Houston, Houston, TX, United States, 6Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 7Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX, United States, 8University of Texas Medical Branch, Galveston, TX, United States, 9Center for Precision Health, UTHealth School of Public Health and UTHealth School of Biomedical Informatic, Houston, TX, Unites States, 10Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, Unites States, 11Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX United States, 12Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States


11:45 AM–12:00 Noon
12
The Association between the Occurrence of Gastroschisis and Maternal Chlamydia Infection among Cases in the Texas Birth Defects Registry, 2013–2017
Shumate CJ1, Russell K2, Navarro Sanchez ML3, Le M1, Canfield MA4. 1Texas Department of State Health Services, Austin, TX, United States, 2Maternal and Child Health Epidemiology, Texas Department of State Health Services, Austin, TX, United States, 3Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 4Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States


12:00 Noon–12:15 PM
13
Maternal Vitamin D Status and Risk of Select Birth Defects in the National Birth Defects Prevention Study (1997–2011)
Adrien N1, Yazdy M2, Nestoridi E2, Carmichael SL3, Orta OR4. 1Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States, 2Massachusetts Center for Birth Defects Research and Prevent, Department of Public Health, Boston, MA, United States, 3Department of Pediatrics and Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, United States, 4Boston University School of Public Health, Department of Epidemiology, Boston, MA, United States


12:15 PM–12:30 PM
14
Unique Clusters of Sudden Unexpected Infant Death (SUID) Decedents Revealed Through Machine Learning Epidemiological Analyses
Blackburn J1, Chapur VF2, Stephens JA3, Zhao J3, Shepler A4, Pierson CR5, Otero JJ6. 1The Ohio State University, Columbus, OH, United States, 2Instituto de Ecoregiones Andinas (INECOA)/Consejo Nacional de investigaciones científicas y técnicas, San Salvador de Jujuy, Argentina, 3The Ohio State University, Center for Biostatistics, Columbus, OH, United States, 4Franklin County Forensic Science Center, Columbus, OH, United States, 5Nationwide Children's Hospital, Department of Pathology and Laboratory Medicine, Columbus, OH, United States, 6The Ohio State University, Department of Pathology, Division of Neuropathology, Columbus, OH, United States


11:00 AM–12:30 PM
Platform Session 3
Chairpersons: William Slikker Jr., National Center for Toxicological Research, US FDA and Bevin Blake, National Institute of Environmental Health Sciences
Full Schedule


Presenting author is underlined.


11:00 AM–11:15 AM
15
In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproic Acid Analogues
Chang X1, Kleinstreuer NC2, Casey WM3, Allen DG4, Ceger P4, Bell S4, Mansouri K2, Palmer J5, Donley OO5, Lumen A6, Lee UJD7. 1Integrated Laboratory Systems, LLC, Morrisville, NC, United States, 2NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, NC, United States, 3NIH/NIEHS/DNTP, Research Triangle Park, NC, United States, 4Integrated Laboratory Systems, LLC, Morrisville, NC, United States, 5Stemina Biomarker Discovery Inc., Madison, WI, United States, 6US FDA/NCTR, Jefferson, AR, United States, 7Albert Einstein College of Medicine, Bronx, NY, United States


11:15 AM–11:30 AM
16
Does Nrf2 Play a Role in the Developmental Toxicity of the Sulfate Metabolite of 3,3’-dichlorobiphenyl (PCB-11)?
Roy MA, Gridley CK, Li S, Park Y, Timme-Laragy AR. University of Massachusetts Amherst, Amherst, MA, United States.


11:30 AM–11:45 AM
17
A Data-Driven Model Analysis of Retinoid Signaling in Skeletal Dysmorphogenesis and Potential Adverse Outcome Pathways
Pierro JD1, Baker NC2, Richard AM1, Kleinstreuer NC3, Knudsen TB1. 1US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States, 3NIH/NIEHS/ DNTP/NICEATM, Research Triangle Park, NC, United States


11:45 AM–12:00 Noon
18
The Effects of Low Dose Cadmium on Mouse Embryo Vascular Development In Vitro
Erwin NJ1, Liu J2, Kapron CM3. 1Environmental & Life Sciences, Peterborough, ON, Canada, 2Shandong University / School of Medicine, Jinan, China, 3Trent University, Peterborough, ON, Canada


12:00 Noon–12:15 PM
19
Transcriptome Analysis Reveals Toxicant-Induced miRNA Signatures Associated with Aberrant Human Embryonic Stem Cell Osteoblast Differentiation
Sparks NRL1, Williams D2, zur Nieden NI1. 1University of California, Riverside, Riverside, CA, United States, 2Department of Molecular, Cell, and Systems Biology, College of Natural and Agricultural Sciences, Riverside, CA, United States


12:15 PM–12:30 PM
20
ReproTracker: A Human Stem Cell-Based Biomarker Assay for In Vitro Assessment of Developmental Toxicity
Jamalpoor A, Hartvelt S, Zwetsloot T, Ghoussain N, Osterlund T, Hendriks G. Toxys B.V., Leiden, Netherlands


11:00 AM–12:30 PM
Platform Session 4
Chairpersons: Barbara F. Hales, McGill University and
Madhumita Basu, Nationwide Children's Hospital
Full Schedule


Presenting author is underlined.


11:00 AM–11:15 AM
21
Effects of Bisphenol A and Bisphenol AF on the Murine Limb Bud Transcriptome
McHattie TJ1, Iskandarani L1, Robaire B1,2, Hales BF1. 1Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; 2Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada


11:15 AM–11:30 AM
22
A New Entity: Vascular-Induced Skeletal Dystrophisms of the Lower Limb
Hootnick D1, DeSesso JM2. 1SUNY Upstate Medical University, Syracuse, NY, United States, 2Exponent and Georgetown University School of Medicine, Alexandria, VA, United States


11:30 AM–11:45 AM
23
Alteration of the Expression of Proteins Associated with Radical Glial Scaffold Development in Ethanol-Exposed Forebrain Organoids Derived from Human Embryonic Stem Cells
Chen S1, Lu L1, Yuan F1, Liu J1, Wilkey DW2, Merchant ML2. 1Department of Pharmacology and Toxicology, University of Louisville Health Science Center, Louisville, KY, United States, 2Department of Medicine, University of Louisville Health Science Center, Louisville, KY, United States


11:45 AM–12:00 Noon
24
Using Live Imaging and FUCCI ESC to Provide QC for a DevTox HTS and to Define Stressful Doses of PFOA and DEP
Rappolee DA1, Abdulhasan M1, Ruden X1, You Y1, Harris S2, Ruden D1, Awonuga A1, Alvero A1, Puscheck 01. 1Wayne State University, Detroit, MI, United States, 2University of Michigan, Ann Arbor, MI, United States


12:00 Noon–12:15 PM
25
Aryl Hydrocarbon Receptor Mediated Disruption of Dopaminergic and Serotonergic Signaling in the Hippocampus and Prefrontal Cortex of Mice Exposed to Benzo[a]pyrene during Development
Foster E, Clough K, Curran CP. Northern Kentucky University, Highland Heights, KY, United States


12:15 PM–12:30 PM
26
Exposure to Flame Retardants and Surfactants In Utero and Biomarkers of Human Placental Development and Disease
Varshavsky J1, Robinson JF1, Zhou Y1, Puckett K1, Buarpung S1, Aburajab R1, Gaw S1, Sen O2, Crispo Smith S3, Frankenfield J3, Park J-S3, Fisher S1, Woodruff T1. 1University of California, San Francisco, San Francisco, CA, United States, 2The University of Tennessee Health Science Center, Memphis, TN, United States, 3Department of Toxic Substances Control, Berkeley, CA, United States


12:30 PM–1:00 PM
Break


1:00 PM–3:00 PM
CME
Cannabis in Pregnancy and Through Generations Symposium
Organized by the Public Affairs Committee
Chairpersons: Poorni R. Iyer, California EPA and
Marlissa Campbell, California EPA
Full Schedule


1:00 PM–1:05 PM
Introduction
Poorni R. Iyer, California EPA and
Marlissa Campbell, California EPA


1:05 PM–1:30 PM
S14
A Review of Epidemiological Evidence in Humans of the Effects of Prenatal Exposure to Cannabis (Smoke and Δ9-THC).
Farla Kaufman, California EPA


1:30 PM–1:55 PM
S15
A Clinical Perspective on Cannabis Use During Pregnancy
Torri Metz, University of Utah Health


1:55 PM–2:20 PM
S16
Perinatal Exposure to Δ9-tetrahydrocannabinol Alters Immune Functions in Fetal and Postnatal Stages of Life: Role of Epigenetic Pathways
Prakash Nagarkatti, University of South Carolina School of Medicine


2:20 PM–2:45 PM
S17
Epigenetic Effects of Cannabis on the Developing Brain
Anissa Bara, Icahn School of Medicine at Mount Sinai


2:45 PM–3:00 PM
Discussion


1:00 PM–3:00 PM
HESI Symposium
Nonclinical Considerations for Inclusion of Pregnant and Lactating Women in Clinical Trials

Chairpersons: Kary Ellen Thompson, Janssen Pharmaceuticals and
Dinesh J. Stanislaus, GlaxoSmithKline

Full Schedule


1:00 PM–1:05 PM
Introduction
Kary Ellen Thompson, Janssen Pharmaceuticals


1:05 PM–1:30 PM
S18
The Time is Now: Why We Must Include Pregnant and Lactating Women in Drug Development
Belen Tornesi, Medicines for Malaria Venture


1:30 PM–1:55 PM
S19
Nonclinical Evaluation of Medicines Used in Pregnancy/Lactation: Looking Back to Move Forward
Dinesh J. Stanislaus, GlaxoSmithKline


1:55 PM–2:20 PM
S20
Considerations for Evolution of the Nonclinical Toxicology Paradigm to Enable Clinical Trials in Pregnant/Lactating Patients
Kary Ellen Thompson, Janssen Pharmaceuticals


2:20 PM–2:45 PM
S21
Making Nonclinical Data Meaningful: Communicating Data and Risk Assessment with HCP and Women
Wendy Halpern, Genentech


2:45 PM–3:00 PM
Discussion


1:00 PM–3:00 PM
Current Topics and Updates for Pregnancy Registries Workshop
(Joint with OTIS)

Chairpersons: Lewis B. Holmes, MassGeneral Hospital for Children and
Keele Elise Wurst, GlaxoSmithKline

Full Schedule


1:00 PM–1:05 PM
Introduction


1:05 PM–1:25 PM
W1
Criteria Used for Classifying Abnormalities Identified in the Antiretroviral Pregnancy Registry
Angela Scheuerle, UT Southwestern Medical Center


1:25 PM–1:45 PM
W2
The Inclusion/Exclusion Criteria Used by the North American Antiepileptic Drug (AED) Pregnancy Registry
Lewis B. Holmes, MassGeneral Hospital for Children


1:45 PM–2:05 PM
W3
An Update on the Use of Social Media to Recruit Pregnant People into Pregnancy Registries
Nicole Chavez, Nicole Chavez Public Relations


2:05 PM–2:25 PM
W4
Trends in Antiepileptic Drug Use and individual Treatment Pattern during the First Trimester of Pregnancy: An Evaluation of the German Embryotox Cohort
Hoeltzenbein M, Slimi S, Fietz AK, Onken M, Dathe K, Schaefer C. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Institut für Klinische Pharmakologie und Toxikologie, Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie, Berlin, Germany


2:25 PM–2:45 PM
W5
The Development of a Belgian Prospective Data Registration System on Perinatal Medication Use and Mother-Infant Outcomes: An Introduction to the BELpREG Initiative
Sillis L1, Ceulemans M1, Van Calsteren K2,3, Smits A3,4, Hompes T5,6, Bogaerts A3,7,8, Allegaert K1,3,9, De Vos M3,10, Verbakel JY11,12, Foulon V1. 1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium, 2Department of Obstetrics and Gynecology, University Hospitals Leuven Gasthuisberg, Belgium, 3Department of Development and Regeneration, KU Leuven, Belgium, 4Department of Pediatrics and Neonatology, University Hospitals Leuven Gasthuisberg, Belgium, 5Adult Psychiatry UPC, KU Leuven, Belgium, 6Department of Neurosciences, KU Leuven, Belgium, 7Faculty of Medicine and Health Sciences, University of Antwerp, Belgium, 8Faculty of Health, University of Plymouth, Devon, United Kingdom, 9Department of Clinical Pharmacy, Erasmus MC Sophia’s Children Hospital, the Netherlands, 10Department of Electrical Engineering (ESAT), KU Leuven, Belgium, 11Department of Public Health and Primary Care, KU Leuven, Belgium, 12Nuffield Department of Primary Care Health Sciences, University of Oxford, United Kingdom


2:45 PM–3:00 PM
Discussion


3:00 PM–3:30 PM
Break


3:30 PM–4:30 PM
Poster Session 2
 Attended for Questions & Answers
Posters P18–P34 and LB4–LB7
Poster Listings


 
Presenting author is underlined.

P18      Abstract Withdrawn

P19      The Impact of Timing of In Utero Marijuana Exposure on Fetal Growth
Dodge PA1, Nadolski K1, Kopkau H1, Forrestal K2, Bailey B1. Zablocki V1. 1Central Michigan University College of Medicine, Mount Pleasant, MI, United States, 2Central Michigan University, Mount Pleasant, MI, United States

P20      Abstract Withdrawn

P21      Abstract Withdrawn

P22      A Comparison of Computational Toxicology Test Results with In Vivo and In Vitro Endpoints Related to Mode of Action and the Endocannabinoid System: A Case Study with Chlorpyrifos, Chlorpyrifos-oxon and Δ9Tetrahydrocannabinol
Silva MH, Retired from a Career in Toxicology and Risk Assessment, Davis, CA, United States

P23      Periconceptional Folic Acid Use Prevents Both Rare and Common Neural Tube Defects
Zhou Y, Crider K, Yeung L, Rose CE, Berry RJ, Moore CA. CDC, Atlanta, GA, United States

P24      Maternal Smoking During Pregnancy and Newborn Neurobehavior and Abstinence: A Review of the Literature
Stanfield J1, Corey A2, McCallum M2, Jao NC1, Stroud LR1. 1Brown University, Providence, RI, United States, 2The Miriam Hospital, Providence, RI, United States

P25      Ethanol-Induced Reduction in the Activity of the Putative Enhancers of TFAP2A Contributes to the Repression of TFAP2A and Apoptosis in Ethanol-Exposed Human Neural Crest Cells
Chen S-y1, Yuan F1, Lu L2, Liu J1. 1Department of Pharmacology and Toxicology, University of Louisville Health Science Center, Louisville, KY, United States, 2Department of Pharmacology and Toxicology, University of Louisville Health Science Center, Tampere, Finland

P26      The Impact of In Utero Opioid Exposure on Newborn Outcomes: Results from a Matched Cohort Study
Bailey BA1, Justice N2, Shah D2, Wood DL2. 1Central Michigan University College of Medicine, Mt. Pleasant, MI, United States, 2East Tennessee State University, Quillen College of Medicine, Johnson City, TN, United States

P27      Fluoride Exposure and Hypothyroidism in a Canadian Pregnancy Cohort  
Hall MK1, Green R1, Goodman CV1, Farmus L1, Lanphear B2, Martinez-Mier EA3, Hornung R4, Ayotte P5, Till 06. 1Faculty of Health, York University, Toronto, ON, Canada, 2Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, 3Indiana University School of Dentistry, Indianapolis, IN, United States, 4Retired, Loveland, OH, United States, 5Québec National Institute of Public Health, Québec City, QC, Canada, 6York University, Toronto, Toronto, ON, Canada

P28      Predictors of Medicaid Case Management among Infants in the Texas Birth Defects Registry, 2010–2015
Navarro Sanchez ML1, Shumate CJ2, Betancourt D2, Canfield MA3. 1Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 2Texas Department of State Health Services, Austin, TX, United States, 3Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States

P29      Skeletal Ossification Terminology and Criteria Harmonization
Posobiec L1, KOPP C2, Murzyn S1, Olitan T3, Rendemonti J1, French J4, Tamborini E5, Campey J6, Longo 05, Danberry T1, Vaillencourt M7, Sprigden D6, Nowland W8, Daoud M9, Qualls C10, Harris SB11. 1GSK, Collegeville, PA, United States, 2CRL Ashland, Ashland, OH, United States, 3BMS, New Brunswick, NJ, United States, 4Syngenta, Berkshire, United Kingdom, 5Accelera, Nerviano, Italy, 6Covance, Harrogate, United Kingdom, 7CRL, Laval, QC, Canada, 8Pfizer, New Haven, CT, United States, 9CRL, Hertogenbosch, Netherlands, 10Covance, Greenfield, IN, United States, 11Stephen B. Harris Group, San Diego, CA, United States

P30      Factors Associated with Distance to Hospital for First Surgical Repair among Infants with Myelomeningocele in California
Kancherla V1, Ma C2, Purkey N3, Hintz SR3, Lee HC3, Grant G3, Carmichael SL4. 1Emory University, Atlanta, GA, United States, 2Stanford University, Stanford, CA, United States, 3Stanford University School of Medicine, Stanford, CA, United States, 4Department of Pediatrics and Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, United States

P31      Implementation of Cardiorespiratory Monitoring in the Juvenile Minipig Using a Noninvasive Jacketed Telemetry System
Penard L1, Flenet T2, Eynard C2, Bouillon C2, Bory C3, Baudet S3, Marsden E3. 1Charles River, Saint Germain Nuelles, France, 2Etisense, Lyon, France, 3Charles River, Saint Germain-Nuelles, France

P32      Abstract withdrawn.

P33      Adult Learning and Memory in Three Genotypes of Mice Exposed to Benzo[a]Pyrene During Early Brain Development
Clough K, Foster E, Perry C, Mullaguru J, Honaker A, Towell A, Curran CP. Northern Kentucky University, Highland Heights, KY, United States

P34      Preconception and Prenatal Arsenic Exposure and Gene Expression Alterations in Liver, Placenta, Heart, and Lung
Rychlik KA1, Kashiwagi C2, Liao J2, Tran V2, Mathur A2, Illingworth E2, Sanchez S2, Kleensang A2, Maertens 02, Sillé, FCM2. 1The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States, 2Johns Hopkins University, Baltimore, MD, United States

LB4      The Applicability of Female and Male Human Neural Progenitor Cells for Sex-Specific Developmental Neurotoxicity Testing: A Case Study
Faustman EM1, Leme DM2, Suh YP1, Park JJ1, Lee JH1, Workman T1, Smith M1, Griffith WC1. 1Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA, United States. 2Department of Genetics, Federal University of Paraná, Curitiba, PR, Brazil

LB5      Modeling Neural Tube Defects with Self-Organizing Single Rosette Cortical Spheroids (SOSRS): A Structurally Reproducible Brain Organoid Technology
Tidball AM1, Niu W1, Takla T1, Ma Q2, Varela MC3. 1Department of Neurology, University of Michigan, Ann Arbor, MI, United States, 2Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States, 3Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, United States

LB6      Mitigation of Dolutegravir Developmental Toxicity in Mice by Folic Acid
Tukeman GL, Wei H, Włodarczyk B, Lin Y, Finnell RH, Cabrera RM. Baylor College of Medicine, Houston, TX, United States

LB7      Paternal Alcohol Exposures Induce Craniofacial Malformations: Male Inherited Teratogenesis and the Epigenetic Programming of Congenital Defects
Thomas KN, Lunde R, Bedi YS, Roach AN, Thomas K, Mehta NA, Srikanth N, Golding MC. Department of Physiology, Golding Lab, Texas A&M University, College Station, TX, United States

Wednesday, June 30, 2021
11:00 PM–12:00 Noon
Innovator Award Finalists Platform Session 5
 Chairperson: Kembra L. Howdeshell, National Institute of Environmental Health Sciences
Full Schedule


Presenting author is underlined.


11:00 AM–11:20 AM
27
Transcriptomic and Proteomic Profiling of Alternative Flame Retardant Exposures in Human Embryonic Stem Cell Neural Derivatives
Chen H1, Jigmeddagva U1, Williams KE1, Hunter CL2, Yan CD1, Iyer NS1, Robinson JF1. 1University of California, San Francisco, San Francisco, CA, United States, 2SCIEX, Redwood City, CA, United States


11:20 AM–11:40 AM
28
Exome Sequencing Findings in 115 Children with Annular Pancreas
Pitsava G1, Pankratz N2, Lane J2, Yang W3, Rigler S4, Shaw GM5, Mills JL1. 1NICHD, NIH, Bethesda, MD, United States, 2Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, United States, 3Department of Pediatrics, Stanford University School of Medicine, Standford, CA, United States, 4Department of Neonatology, Naval Medical Center Portsmouth, Portsmouth, VA, United States, 5Standford University School of Medicine, Standford, CA, United States


11:40 AM–12:00 Noon
29
Newborn Screening Analytes and Structural Birth Defects: Evaluating Novel Associations using a Phenotypic Spectrum Analysis
Lupo PJ1, Archer NP2, Marengo LK2, Hoyt AT2, Drummond-Borg M2, Freedenberg D2, Langlois PH3, Canfield MA3. 1Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States, 2Texas Department of State Health Services, Austin, TX, United States, 3Birth Defects Epidemiology and Surveillance, Texas Department of State Health Services, Austin, TX, United States


12:00 Noon–12:30 PM
Warkany Tea


12:30 PM–1:00 PM
Break


1:00 PM–3:00 PM
CME
Molecular Mechanisms of Fetal Alcohol Spectrum Disorders (FASD) in Humans and Animal Models Symposium
(Joint with DNTS)
Chairpersons: Peter G. Wells, University of Toronto and
Rajesh C. Miranda, Texas A&M Health Science Center
Full Schedule


1:00 PM–1:05 PM
Introduction
Peter G. Wells, University of Toronto


1:05 PM–1:30 PM
S22
Oxidative DNA Damage and Repair and Epigenetic Mechanisms in Fetal Alcohol Spectrum Disorders (FASD)
Peter G. Wells, University of Toronto


1:30 PM–1:55 PM
S23
Epigenetic Mechanisms: Endocrine miRNAs in Pregnant Women, Predictive of FASD Infant Outcomes, Inhibit Placental Maturation and Result in Fetal Growth Restriction
Rajesh C. Miranda, Texas A&M Health Science Center


1:55 PM–2:20 PM
S24
Neural Stem Cell Modeling of FASD: Mouse Strain- and Sex-dependent Effects of Alcohol on DNA Methylation
Mojgan Rastegar, University of Manitoba


2:20 PM–2:45 PM
S25
Transcriptomic Analyses Identify Genetic Modifiers of Adult Cardiometabolic Disease Risk in Zebrafish Following Embryonic Alcohol Exposure
Wolfram Goessling, Brigham and Women’s Hospital, Harvard Medical School


2:45 PM–3:00 PM
Discussion


1:00 PM–3:00 PM
Refining Toxicology Testing to Detect Endocrine Disrupting Chemicals Symposium
Chairpersons: Kembra L. Howdeshell, National Institute of Environmental Health Sciences and Heather B. Patisaul, North Carolina State University
Full Schedule


1:00 PM–1:05 PM
Introduction
Kembra L. Howdeshell, National Institute of Environmental Health Sciences


1:05 PM–1:30 PM
S26
Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA): Findings and Considerations for Future Guideline Toxicity Testing of Endocrine Disrupting Chemicals
Kembra L. Howdeshell, National Institute of Environmental Health Sciences


1:30 PM–1:55 PM
S27
Detecting Endocrine Disruption of Brain and Behavior
Heather B. Patisaul, North Carolina State University


1:55 PM–2:20 PM
S28
Validation of In Vitro Thyroid Mechanistic Methods Based On the Organization of Economic Co-operation and Development Scoping Document
Sandra Coecke, European Commission


2:20 PM–2:45 PM
S29
Case-Study Applications Using Evidence-Based Approaches to Assess Endocrine Activity for Risk Assessment
Daniele Wikoff, ToxStrategies, Inc.


2:45 PM–3:00 PM
Discussion


3:00 PM–3:30 PM
Break


3:30 PM–4:30 PM
Poster Session 3
 Attended for Questions & Answers
Posters P35–P51 and LB8–LB10
Poster Listings


 
Presenting author is underlined.

P35      Abstract Withdrawn

P36      Developmental Toxicity Study in the Dog
Elsom T, Clubb SK. Charles River Laboratories, Edinburgh, United Kingdom

P37      Systematic Evidence Mapping to Support an Evaluation of ~430 PFAS Chemicals
Carlson LM1, Hubbard H2, Shirke A3, Angrish MM4, Lin C2, Vetter N2, Thayer K4. 1US EPA, Durham, NC, United States, 2ICF International, Durham, NC, United States, 3US EPA Office of Research and Development, Center for Public Health and Environmental Assessment, Washington, DC, United States, 4US EPA Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, NC, United States, 7US EPA Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, NC, United States

P38      Systematic Assessment of QUATs for the Potential to Elicit Developmental and Reproductive Effects
DeSesso JM1, Harris SB2, Scialli AR3, Williams AL4. 1Exponent and Georgetown University School of Medicine, Alexandria, VA, United States, 2Stephen B. Harris Group, San Diego, CA, United States, 3Scialli Consulting LLC, Washington, DC, United States, 4Exponent, Alexandria, VA, United States

P39      Antifungal Medication Use in Pregnancy and the Risk of Major Birth Defects in the National Birth Defects Prevention Study, 1997–2011
Papadopoulos EA1, Howley MM1, Fisher SC1, Van Zutphen AR1, Werler MM2, Romitti PA3, Browne ML1. 1New York State Department of Health, Albany, NY, United States, 2Boston Univeristy, Boston, MA, United States, 3University of Iowa, Iowa City, IA, United States

P40      DNA Double-Strand Breaks in Fetal Brains from Oxoguanine Glycosylase 1 (Ogg1) Knockout Mice Exposed In Utero to Physiological or Ethanol-enhanced Levels of Reactive Oxygen Species (ROS)
Cheng A1, Yan W2, Wells PG1,2. 1Dept. of Pharmaceutical Sciences and Centre for Pharmaceutical Oncology (CPO), University of Toronto, Toronto, ON, Canada, 2Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada

P41      A Systematic Review of Antiepileptic Drug Exposure during Pregnancy and Neonatal Birthweight Outcomes and Interim Meta-Analysis
Lavu A1, Vaccaro C2, Shouman W2, Alessi-Severini S2, Eltonsy S2. 1College of Pharmacy, University of Manitoba, Winnipeg, MB, Canada, 2College of Pharmacy, Rady Faculty of Health Sciences, Winnipeg, MB, Canada

P42      Lateral Epiphyseal Reductions due to Vascular Dysgenesis are Hypothesized to Cause Congenital Valgus Deformities at the Knee and Ankle in Fibular Deficient Limbs
Krisch M, Hootnick D, Horton J. SUNY Upstate Medical University, Syracuse, NY, United States

P43      Using Live Imaging and FUCCI ESC to Distinguish G1 Cell Cycle Delays for General Stressors like PFAS and Phthalates or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a) pyrene
Rappolee DA1, Ruden X1, Abdulhasan M1, Harris S2, Ruden D1, Puscheck E

P44      Use of Fulvestrant as an Anti-Estrogenic Positive Control Substance in Uterotrophic Bioassays
Davis SM, Coder PS, Huang J. Charles River Laboratories, Ashland, OH, United States

P45      New Variants for Transverse Limb Deficiency Defects from Whole Exome Sequencing: The National Birth Defects Prevention Study
Gomez-Acevedo H1, Nembhard WN1, Moore CA2, Jenkins MM2, Almli LM2, Lou X-Y3, Reefhuis J2, Shaw GM4, Romitti 005, Werler MM6, Yazdy MM7, Olshan AF8, Kay DM9, Finnell RH10, Feldkamp ML11, Bamshad M12, Brody L13, Mullikin j13, Pangilinan F13, Nickerson D14, McGoldrick DJ14. 1University of Arkansas for Medical Sciences, Little Rock, AR, United States, 2CDC, Atlanta, GA, United States, 3University of Florida, Gainesville, FL, United States, 4Standford University School of Medicine, Standford, CA, United States, 5University of Iowa, Iowa City, IA, United States, 6Boston Univeristy, Boston, MA, United States, 7Massachusetts Center for Birth Defects Research and Prevention, Boston, MA, United States, 8University of North Carolina, Chapel Hill, NC, Unites States, 9New Your State Department of Health, Albany, NY, United States, 10Baylor College of Medicine, Houston, TX, United States, 11University of Utah School of Medicine, Salt Lake City, UT, United States, 12University of Washington SOM, Seattle, WA, United States, 13NHGRI NIH, Bethesda, MD, United States, 14University of Washington Genome Sciences, Seattle, WA, United States

P46      Psychosocial Stress During Pregnancy Affects Placental Programming of Hypothalamic Pituitary Adrenal Axis
Ruyak SL1, Milligan E2, Solomon E3, Allen A2, Ma X4, Weinburg J5, Roberts M4, Rodriguez D4, Enriquez Marquez 04, Rai R4, Stacy L4, Jacobson S6, Bakhireva L4. 1University of New Mexico, College of Nursing, Albuquerque, NM, United States, 2University of New Mexico, Department of Neuroscience, Albuquerque, NM, United States, 3University of New Mexico, Department of Neuroscience, Louisville, KY, United States, 4University of New Mexico, College of Pharmacy, Albuquerque, NM, United States, 5The University of British Columbia, Department of Cellular and Physiological Sciences, Vancouver, BC, Canada, 6Wayne State University, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, United States

P47      Developmental Toxicity in CF-1 Mice after Gestational Opioid Exposure
Kaldhone PR1, Han T1, Krishnavenisivakumar K1, Phanavanh B1, Moland C1, Felton R1, Lee G2, Mellon D2, Fisher 02, Hanig, J2, Beger RD1, Inselman AR1. 1US FDA/NCTR, Jefferson, AR, United States, 2US FDA/CDER, Silver Spring, MD, United States

P48      Evaluating the Utility of Clinical Exome Sequencing for the Molecular Diagnosis of Nonisolated Microphthalmia, Anophthalmia, and Coloboma (MAC)
Martin-Giacalone BA1, Scott DA2, Mitchell LE3, Hufnagel RB4, Brooks BP4, Lewis RA1, Agopian AJ5, Lupo PJ6. 1Baylor College of Medicine, Houston, TX, United States, 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States, 3University of Texas School of Public Health, Houston, TX, United States, 4National Eye Institute, Bethesda, MD, United States, 5Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 6Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States

P49      Patterns of Co-occurring Birth Defects among International Surveillance Systems  
Navarro Sanchez ML1, Benjamin RH1, Agopian AJ1, Ludorf KL1, Chen H2, Canfield MA3, Swartz MD4, Scheuerle AE5. Scott 006, Stangenes M7, Stallings EB8, Scarano G9, Bermejo-Sanchez E10, Rissmann A11, Mutchinick OM12, Landau D13, Kurasawa K14, Kiuru-Kuhlefelt S15, Khoshnood B16, Källén K17, Cocchi G18, Lopez Camelo J19, De Walle HEK20, Csáky-Szunyogh M21, Botto LD22, Amar E23, Lupo PJ24. 1Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States, 2Center for Precision Health, UTHealth School of Public Health and UTHealth School of Biomedical Info, Houston, TX, United States, 3Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 4Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, United States, 5Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical, Dallas, TX, United States, 6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, Unites States, 7Department of Health Registry Research and Development, Norwegian Institute of Public Health, Bergen, Norway, 8National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 9U.O. di Genetica Medica, A.O.R.N., Bologna, Italy, 10ECEMC, Research Unit on Congenital Anomalies (UIAC) Instituto de Investigación de Enfermedades Raras, Madrid, Spain, 11Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, 12Registro y Vigilancia Epidemiológica de Malformaciones Congénitas (RYVEMCE) Department of Genetics, Mexico, 13Department of Obstetrics and Gynecology, Soroka University Medical Center, Be'er Sheva, Israel, 14Department of Obstetrics and Gynecology, Yokohama City University, Yokahama, Japan, 15Information Services Department, Health and Social Services Data and Information Management, Finni, Helsinki, Finland, 16Université de Paris, CRESS, INSERM, INRA, Paris, France, 17National Board of Health and Social Welfare, Stockholm, Sweden, 18Neonatology Unit, Department of Pediatrics, University of Bologna, Bologna, Italy, 19ECLAMC, Center for Medical Education and Clinical Research (CEMIC-CONICET), Buenos Aires, Argentina, 20University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Groningen, Netherlands, 21Hungarian Congenital Abnormalities Registry and Rare Disease Centre, National Public Health CenterBudapest, Hungary, 22International Center on Birth Defects (ICBD) of the International Clearinghouse for Birth Defects Su, Rome, Italy, 23REMERA, Rhône-Alps registry of birth defects, Hospices Civils de Lyon, France, Lyon, France, 24Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States

P50      Measures of Anxiety in Mice Vary by Genotype, But Not Treatment Following Developmental Exposure to Benzo[a]pyrene
Honaker A, Perry C, Curran CP. Northern Kentucky University, Highland Heights, KY, United States

P51      Noonan Syndrome with Multiple Lentigines and Pigmented Villonodular Synovitis in Multiple Generations: Insight into the Pathogenesis of a Benign Tumor
Kramer EF1, Jonasson AR2, Gripp KW3, Rasmussen SA1. 1Dept. of Pediatrics, University of Florida College of Medicine, Gainesville, FL, United States, 2Dept. of Pediatrics, Div. of Genetics and Metabolism, University of Florida, Gainesville, FL, United States, 3Div. of Medical Genetics, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE United States

LB8      Harnessing New Approach Methodologies for Predictive DART and Endocrine Disruption in Plant Protection Product Development
Bianchi E, LaRocca J. Corteva Agriscience, Indianapolis, IN, United States

LB9      Evaluating Neonatal Reflexes in cyp1a1(-/-) Knockout and Wild Type Mice Exposed to Benzo[a]Pyrene during Early Brain Development
Kyntchev A, CloughnK, Foster E, Curran CP. Northern Kentucky University, Highland Heights, KY, United States

LB10    Metal Mixtures Elicit Differential Effects in a Human Brain Organoid Model
Kincaid BJ, Smirnova L, Modafferi S, Hogberg H, Kleensang A, Hartung T. Johns Hopkins School of Public Health, Baltimore, MD, United States

4:30 PM–5:30 PM
BDRP 40th Annual Volleyball Game, A Virtual NETworking Event


Thursday, July 1, 2021
11:00 AM–12:30 PM
Transforming Women’s Health Through Better Information on the Safety of Medications During Pregnancy and Lactation Symposium
(Joint with OTIS)
Chairpersons: Janet R. Hardy, Biohaven Pharmaceuticals and Elizabeth A. Conover, University of Nebraska Medical Center
Full Schedule


11:00 AM–11:05 AM
Introduction
Elizabeth A. Conover, University of Nebraska Medical Center


11:05 AM–11:25 AM
S30
Overview of PRGLAC
Leyla Sahin, US Food and Drug Administration


11:25 AM–11:45 AM
S31
Introduction to the ConcePTION Initiative
Marie Teil, UCB Pharma


11:45 AM–12:05 PM
S32
PRGLAC: Data Gaps and Srategies
Janet R. Hardy, Biohaven Pharmaceuticals


12:05 PM–12:30 PM
Discussion
Melissa S. Tassinari, Consultant


11:00 AM–12:30 PM
Hot Topic Symposium
Assessing Reproductive Risks from Fracking and Mountaintop Mining
Chairpersons: Christine Perdan Curran, Northern Kentucky University and
Philip Lupo, Baylor College of Medicine
Full Schedule


11:00 AM–11:05 AM
Introduction
Philip Lupo, Baylor College of Medicine


11:05 AM–11:20 AM
S33
Intensity of Oil and Gas Well Site Activities in Early Pregnancy and the Risk of Structural Birth Defects
Lisa McKenzie, Colorado School of Public Health


11:20 AM–11:35 AM
S34
Drinking Water Vulnerability and Neonatal Health Outcomes in Relation to Oil and Gas Production in the Appalachian Basin
Nicole Deziel, Yale University School of Public Health


11:35 AM–11:50 AM
S35
Using Animal Studies to Understand Reproductive Risks Associated with Inhalation Exposures to Particles
Timothy Nurkiewicz, West Virginia University


11:50 AM–12:05 PM
S36
Fuel for Thought: Summing Up the Risks from Unconventional Energy Extraction
Christine Perdan Curran, Northern Kentucky University


12:05 PM–12:30 PM
Discussion


12:30 PM–1:00 PM
Break


1:00 PM–3:00 PM
New Frontiers in Developmental Toxicity Testing for Environmental Chemicals Workshop
Organized by the Science Committee
Chairpersons: Thomas B. Knudsen, US Environmental Protection Agency and
Susan Y. Euling, US Environmental Protection Agency
Full Schedule


1:00 PM–1:05 PM
Introduction
Susan Y. Euling, US Environmental Protection Agency


1:05 PM–1:30 PM
W6
Challenges and Opportunities: Building NAMs to Reflect Developmental Stage Complexity
Elaine M. Faustman, University of Washington


1:30 PM–1:55 PM
W7
Scaling Up: Zebrafish Social Interaction as Scalable Phenotype for Identifying Neurodevelopmental Toxicants and Their Mechanisms
Randall T. Peterson, University of Utah


1:55 PM–2:20 PM
W8
Single-Cell RNA-Sequencing Analysis of Early Cardiogenesis Reveals Cell-Type-Specific Perturbations that Drive Organ-Level Developmental Defects upon Hand2 Loss
Yvanka De Soysa, Boston Children’s Hospital


2:20 PM–2:45 PM
W9
Predictive Developmental Toxicity with Pluripotent Stem Cell Models and ToxCast/Tox21 Assay Batteries
Thomas B. Knudsen, US Environmental Protection Agency


2:45 PM–3:00 PM
Discussion


3:00 PM–3:30 PM
Break


3:30 PM–4:30 PM
Annual Meeting Awards Presentation and
Business Meeting
Wilson Presentation Awards
Marie Taubeneck Award
James C. Bradford Memorial Student Poster Awards
BDRP Innovator Award
Birth Defects Research Distinguished Scholar Award
Edward W. Carney Distinguished Service Award
Recognition of Other Awards Presented throughout the Week
Annual Business Meeting


Thursday, July 15, 2021
11:00 AM–2:30 PM
Education Course Session 1
Development and Disorders of the Gastrointestinal (GI) Tract
(Separate Registration Required)
Organized by the Education Committee
Chairperson: Christina M. Carruthers, Janssen Pharmaceuticals
Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Christina M. Carruthers, Janssen Pharmaceuticals


11:05 AM–11:45 AM
Early Development of the GI Tract
Wendy Halpern, Genentech


11:45 AM–12:25 PM
Mechanisms of Gut Stem Cell Niches in Early Postnatal Gut Development and Necrotizing Enterocolitis
Tae-Hee Kim, The Hospital for Sick Children, University of Toronto


12:25 PM–12:40 PM
Discussion


12:40 PM–12:55 PM
Break


12:55 PM–1:35 PM
Embryology and Pathogenesis of Gastroschisis
Marcia Lynn Feldkamp, University of Utah


1:35 PM–2:15 PM
Clinical Management
Suna Seo, US Food and Drug Administration


2:15 PM–2:30 PM
Discussion


Thursday, July 22, 2021
11:00 AM–2:30 PM
Education Course Session 2
Craniofacial Morphogenesis and Teratogenesis
(Separate Registration Required)
Organized by the Education Committee
Chairperson: Christina M. Carruthers, Janssen Pharmaceuticals
Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Christina M. Carruthers, Janssen Pharmaceuticals


11:05 AM–11:45 AM
Embryological/Morphological Development of the Craniofacial Region
John DeSesso, Exponent


11:45 AM–12:25 PM
Mouse Models of Craniofacial Morphogenesis and Malformations
Robert Lipinski, University of Wisconsin


12:25 PM–12:40 PM
Discussion


12:40 PM–12:55 PM
Break


12:55 PM–1:35 PM
Craniofacial Morphogenesis and Teratogenesis
Brian Johnson, Michigan State University


1:35 PM–2:15 PM
Management of Craniofacial Anomalies
Marilyn Jones, Rady Children’s Hospital


2:15 PM–2:30 PM
Discussion


Thursday, July 29, 2021
11:00 AM–1:00 PM
Mini Course
Single-Cell RNA Sequencing in Understanding Normal and Abnormal Development
(Separate Registration Required)
Sponsored by Alan M. Hoberman, in memory of Robert L. Brent
Organized by the Education Committee
Chairperson: Christina M. Carruthers, Janssen Pharmaceuticals
Full Schedule


11:00 AM–11:05 AM
Course Overview
Education Committee, Chairperson, Christina M. Carruthers, Janssen Pharmaceuticals


11:05 AM–11:30 AM
Single-Cell Profiling for Advancing Birth Defects Research and Prevention
Thomas B Knudsen, US EPA


11:30 AM–11:55 AM
Technical Considerations for Single-Cell RNAseq Workflows
David Gallegos, US EPA


11:55 AM–12:20 PM
Analytical Approaches to Dissect Dysregulated Gene Expression and Developmental Trajectories
Yvanka de Soysa, Boston Children's Hospital


12:20 PM–12:45 PM
Prospects for Profiling Developmental Toxicity with Single-Cell Resolution
Joshua F. Robinson, University of California, San Francisco


12:45 PM–1:00 PM
Discussion


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